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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n11http://linked.opendata.cz/resource/drugbank/drug/DB08810/identifier/kegg-drug/
n13http://linked.opendata.cz/resource/drugbank/drug/DB08810/identifier/drugbank/
n12http://bio2rdf.org/drugbank:
admshttp://www.w3.org/ns/adms#
n7http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n9http://linked.opendata.cz/resource/drugbank/drug/DB08810/identifier/wikipedia/
n10http://linked.opendata.cz/resource/drugbank/drug/DB08810/identifier/pharmgkb/

Statements

Subject Item
n2:DB08810
rdf:type
n3:Drug
n3:description
Cinitapride is a gastroprokinetic agent and antiulcer agent of the benzamide class which is marketed in Spain and Mexico. It acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors.
n3:generalReferences
# Alarcon-de-la-Lastra Romero C, Lopez A, Martin MJ, la Casa C, Motilva V: Cinitapride protects against ethanol-induced gastric mucosal injury in rats: role of 5-hydroxytryptamine, prostaglandins and sulfhydryl compounds. Pharmacology. 1997 Apr;54(4):193-202. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9211565
n3:group
approved
n3:halfLife
3-5 h during the first 8 h and a residual half-life greater than 15 h thereafter.
n3:indication
For the treatment of gastrointestinal disorders associated with motility disturbances such as gastroesophageal reflux disease, non-ulcer dyspepsia and delayed gastric emptying.
owl:sameAs
n7:DB08810 n12:DB08810
dcterms:title
Cinitapride
adms:identifier
n9:Cinitapride n10:PA165958427 n11:D07700 n13:DB08810
n3:mechanismOfAction
Cinitapride is a substituted benzamide with 5-HT receptor antagonist and agonist activity.
n3:synonym
Paxapride
n3:toxicity
The symptoms of overdose include drowsiness, confusion and extrapyramidal effects.
n3:IUPAC-Name
n4:271B5648-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B564E-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B564D-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B564A-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B564B-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B564C-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B5646-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B5647-363D-11E5-9242-09173F13E4C5 n4:271B5644-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B5645-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n4:271B5654-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B5655-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B564F-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B5650-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B5652-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B5651-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B5653-363D-11E5-9242-09173F13E4C5
n3:absorption
The absorption of cinitapride (12mg) following oral administration was rapid, with peak levels being achieved 2 h after dosing; absorption following intramuscular administration (4mg) was even more rapid, with peak levels (50% more that oral levels) being achieved 1 h after dosing.
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
66564-14-5
n3:Bioavailability
n4:271B565A-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B565C-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B565D-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B5659-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B5658-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B565B-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B5649-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B5656-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B5657-363D-11E5-9242-09173F13E4C5