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Namespace Prefixes

PrefixIRI
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n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n13http://linked.opendata.cz/resource/mesh/concept/
n6http://linked.opendata.cz/resource/drugbank/drug/DB08805/identifier/wikipedia/
n7http://linked.opendata.cz/resource/drugbank/drug/DB08805/identifier/kegg-compound/
n11http://bio2rdf.org/drugbank:
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n8http://linked.opendata.cz/resource/drugbank/drug/DB08805/identifier/kegg-drug/
n16http://linked.opendata.cz/resource/drugbank/drug/DB08805/identifier/iuphar/
n18http://linked.opendata.cz/resource/drugbank/drug/DB08805/identifier/drugbank/
n10http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
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n3http://linked.opendata.cz/ontology/drugbank/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n17http://linked.opendata.cz/resource/drugbank/drug/DB08805/identifier/chemspider/

Statements

Subject Item
n2:DB08805
rdf:type
n3:Drug
n3:description
Metiamide is a histamine H2-receptor antagonist developed from another H2 antagonist, burimamide. It was an intermediate compound in the development of the successful anti-ulcer drug cimetidine.
n3:group
experimental
n3:indication
Potential in the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion.
owl:sameAs
n10:DB08805 n11:DB08805
dcterms:title
Metiamide
adms:identifier
n6:Metiamide n7:C07449 n8:D05004 n14:110648 n15:1233 n16:1233 n17:1265996 n18:DB08805
n3:mechanismOfAction
Metiamide binds to an H<sub>2</sub>-receptor located on the basolateral membrane of the gastric parietal cell, blocking histamine effects. This competitive inhibition results in reduced gastric acid secretion and a reduction in gastric volume and acidity.
n3:synonym
Metiamidum Methiamide Metiamida
n12:hasConcept
n13:M0013677
n3:IUPAC-Name
n4:271B55BE-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B55C4-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B55C3-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B55C0-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B55C1-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B55C2-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B55BC-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B55D4-363D-11E5-9242-09173F13E4C5 n4:271B55BD-363D-11E5-9242-09173F13E4C5 n4:271B55BA-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B55BB-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n4:271B55CA-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B55CB-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B55C5-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B55C6-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B55C8-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B55C7-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B55C9-363D-11E5-9242-09173F13E4C5
n3:casRegistryNumber
34839-70-8
n3:category
n3:Bioavailability
n4:271B55D0-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B55D2-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B55D3-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B55CF-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B55CE-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B55D1-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B55BF-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B55CC-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B55CD-363D-11E5-9242-09173F13E4C5