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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n14http://linked.opendata.cz/resource/drugbank/drug/DB08803/identifier/chemspider/
n12http://bio2rdf.org/drugbank:
admshttp://www.w3.org/ns/adms#
n10http://linked.opendata.cz/resource/drugbank/drug/DB08803/identifier/wikipedia/
n11http://linked.opendata.cz/resource/drugbank/drug/DB08803/identifier/pharmgkb/
n6http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n13http://linked.opendata.cz/resource/drugbank/drug/DB08803/identifier/kegg-drug/
n8http://linked.opendata.cz/resource/atc/
n15http://linked.opendata.cz/resource/drugbank/drug/DB08803/identifier/drugbank/
n7http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB08803
rdf:type
n3:Drug
n3:description
Tymazoline is a nasal preparation.
n3:generalReferences
# Levrier J, Molon-Noblot S, Duval D, Lloyd KG: A new ex vivo method for the study of nasal drops on ciliary function. Fundam Clin Pharmacol. 1989;3(5):471-82. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2481638 # Lorino AM, Lofaso F, Drogou I, Abi-Nader F, Dahan E, Coste A, Lorino H: Effects of different mechanical treatments on nasal resistance assessed by rhinometry. Chest. 1998 Jul;114(1):166-70. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9674465
n3:group
approved
n3:indication
For the treatment of Inflammation of the lining of the nose and paranasal sinuses and allergic inflammation of nasopharyngeal.
owl:sameAs
n6:DB08803 n12:DB08803
dcterms:title
Tymazoline
adms:identifier
n10:Tymazoline n11:PA165958422 n13:D07373 n14:31478 n15:DB08803
n3:mechanismOfAction
Thymazen causes vasoconstriction of the nasal mucosa, reducing congestion and thus the swelling of the mucosa. Also reduces the secretions from the nose. Thymazen acts on alpha-adrenergic receptors, which reduces local inflammation of the nasal mucosa especially if their cause is an allergy.
n3:synonym
Thymazen
n3:toxicity
A large overdose or accidental oral intake, especially in children, may cause excessive sedation with drowsiness, reduced body temperature, heart rate relief and fluctuations in blood pressure and collapse.
n3:IUPAC-Name
n4:271B5585-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B558B-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B558A-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B5587-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B5588-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B5589-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B5583-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B5584-363D-11E5-9242-09173F13E4C5 n4:271B5581-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B5582-363D-11E5-9242-09173F13E4C5
n7:hasATCCode
n8:R01AA13
n3:H-Bond-Acceptor-Count
n4:271B5591-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B5592-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B558C-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B558D-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B558F-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B558E-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B5590-363D-11E5-9242-09173F13E4C5
n3:casRegistryNumber
24243-97-8
n3:Bioavailability
n4:271B5596-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B5598-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B5599-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B5595-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B5594-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B5597-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B5586-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B5593-363D-11E5-9242-09173F13E4C5