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Namespace Prefixes

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n5http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB08802
rdf:type
n3:Drug
n3:description
Isothipendyl is an antihistamine and anticholinergic used as an antipruritic.
n3:generalReferences
# Moreau A, Dompmartin A, Dubreuil A, Leroy D: Phototoxic and photoprotective effects of topical isothipendyl. Photodermatol Photoimmunol Photomed. 1995 Apr;11(2):50-4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8546983
n3:group
approved
n3:indication
For the topical treatment of itching associated with allergic reactions.
owl:sameAs
n12:DB08802 n14:DB08802
dcterms:title
Isothipendyl
adms:identifier
n10:Isothipendyl n13:PA165958421 n15:D08091 n16:3649 n17:DB08802
n3:mechanismOfAction
Isothipendyl is a selective histamine H1 antagonist and binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
n3:synonym
Actapront
n3:salt
n3:synthesisReference
U.S. Patent 2,974,139.
n7:hasConcept
n8:M0051873
n3:IUPAC-Name
n4:271B556B-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B5571-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B5570-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B556D-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B556E-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B556F-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B5569-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B5567-363D-11E5-9242-09173F13E4C5 n4:271B556A-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B5568-363D-11E5-9242-09173F13E4C5
n5:hasATCCode
n6:R06AD09 n6:D04AA22
n3:H-Bond-Acceptor-Count
n4:271B5577-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B5578-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B5572-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B5573-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B5575-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B5574-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B5576-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
482-15-5
n3:category
n3:Bioavailability
n4:271B557C-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B557E-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B557F-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B5580-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B557B-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B557A-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B557D-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B556C-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B5579-363D-11E5-9242-09173F13E4C5