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Namespace Prefixes

PrefixIRI
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dctermshttp://purl.org/dc/terms/
n17http://linked.opendata.cz/resource/drugbank/drug/DB06804/identifier/chemspider/
n12http://linked.opendata.cz/resource/mesh/concept/
n16http://linked.opendata.cz/resource/drugbank/drug/DB06804/identifier/chebi/
n7http://linked.opendata.cz/resource/drugbank/dosage/
n10http://bio2rdf.org/drugbank:
n9http://linked.opendata.cz/resource/drugbank/drug/DB06804/identifier/wikipedia/
admshttp://www.w3.org/ns/adms#
n15http://linked.opendata.cz/resource/drugbank/drug/DB06804/identifier/pubchem-compound/
n4http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n5http://linked.opendata.cz/ontology/drugbank/
n11http://linked.opendata.cz/ontology/mesh/
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n6http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#

Statements

Subject Item
n2:DB06804
rdf:type
n5:Drug
n5:description
Nonoxynol-9 (N-9) is a typical surfactant used as a vaginal spermicide. Spermicides are locally acting non-hormonal contraceptives. When present in the vagina during intercourse, they immobilize/inactivate/damage and/or kill sperms without eliciting systemic effects. N-9 has been in use for more than 30 years as an over-the-counter (OTC) drug in creams, gels, foams and condom lubricants. It is the most commonly used spermicidal contraceptive in the UK and the USA. In several European countries, spermicides are no longer on the market.
n5:dosage
n7:271B54F4-363D-11E5-9242-09173F13E4C5 n7:271B54F5-363D-11E5-9242-09173F13E4C5 n7:271B54F6-363D-11E5-9242-09173F13E4C5
n5:generalReferences
# Iyer V, Poddar SS: Update on nonoxynol-9 as vaginal spermicide. Eur J Contracept Reprod Health Care. 2008 Dec;13(4):339-50. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/19117251
n5:group
approved withdrawn
n5:indication
Nonoxynol 9 is a surfactant spermicide used for contraception in spermicidal creams, jellies, foams, gel, and lubricants. It is also used in conjuction with other methods of contraception, including condoms, cervical caps and diaphragms.
owl:sameAs
n4:DB06804 n10:DB06804
dcterms:title
Nonoxynol-9
adms:identifier
n9:Nonoxynol-9 n13:99443296 n14:DB06804 n15:72385 n16:445872 n17:65319
n5:mechanismOfAction
Nonoxynol-9 interacts with the lipids in the membranes of the acrosome and the midpiece of the sperm. The sperm membranes are lysed; the acrosome, neck and midpiece of the spermatozoa are loosened and then detached which results in their immobilization and death.
n5:synonym
Nonaethylene glycol mono(nonylphenyl) ether Nonaethylene glycol nonylphenyl ether PEG-9 nonyl phenyl ether 26-(Nonylphenoxy)-3,6,9,12,15,18,21,24-octaoxahexacosan-1-ol Nonoxynol 9 Polyoxyethylene (9) nonyl phenyl ether P-Nonylphenyl polyethylene glycol ether Nonylphenol octa(oxyethylene) ethanol Tergitol NP9
n5:toxicity
The major drawback of nonoxynol-9 is its detergent-type action on epithelial cells and the normal vaginal flora. Detergent-type spermicides alter the vaginal flora, possibly leading to an increased risk of opportunistic infections. These are known to enhance the susceptibility of the epithelium of the lower genital tract to HIV and human papillomavirus infection. N-9 can cause vaginal irritation and allergic vaginitis as well as genital irritation in male partners.
n11:hasConcept
n12:M0026039
n5:IUPAC-Name
n6:271B54FB-363D-11E5-9242-09173F13E4C5
n5:InChI
n6:271B5501-363D-11E5-9242-09173F13E4C5
n5:Molecular-Formula
n6:271B5500-363D-11E5-9242-09173F13E4C5
n5:Molecular-Weight
n6:271B54FD-363D-11E5-9242-09173F13E4C5
n5:Monoisotopic-Weight
n6:271B54FE-363D-11E5-9242-09173F13E4C5
n5:SMILES
n6:271B54FF-363D-11E5-9242-09173F13E4C5
n5:Water-Solubility
n6:271B54F9-363D-11E5-9242-09173F13E4C5
n5:logP
n6:271B54F7-363D-11E5-9242-09173F13E4C5 n6:271B54FA-363D-11E5-9242-09173F13E4C5
n5:logS
n6:271B54F8-363D-11E5-9242-09173F13E4C5
n5:H-Bond-Acceptor-Count
n6:271B5507-363D-11E5-9242-09173F13E4C5
n5:H-Bond-Donor-Count
n6:271B5508-363D-11E5-9242-09173F13E4C5
n5:InChIKey
n6:271B5502-363D-11E5-9242-09173F13E4C5
n5:Polar-Surface-Area--PSA-
n6:271B5503-363D-11E5-9242-09173F13E4C5
n5:Polarizability
n6:271B5505-363D-11E5-9242-09173F13E4C5
n5:Refractivity
n6:271B5504-363D-11E5-9242-09173F13E4C5
n5:Rotatable-Bond-Count
n6:271B5506-363D-11E5-9242-09173F13E4C5
n5:casRegistryNumber
26571-11-9
n5:category
n5:Bioavailability
n6:271B550D-363D-11E5-9242-09173F13E4C5
n5:Ghose-Filter
n6:271B550F-363D-11E5-9242-09173F13E4C5
n5:MDDR-Like-Rule
n6:271B5510-363D-11E5-9242-09173F13E4C5
n5:Number-of-Rings
n6:271B550C-363D-11E5-9242-09173F13E4C5
n5:Physiological-Charge
n6:271B550B-363D-11E5-9242-09173F13E4C5
n5:Rule-of-Five
n6:271B550E-363D-11E5-9242-09173F13E4C5
n5:Traditional-IUPAC-Name
n6:271B54FC-363D-11E5-9242-09173F13E4C5
n5:pKa--strongest-acidic-
n6:271B5509-363D-11E5-9242-09173F13E4C5
n5:pKa--strongest-basic-
n6:271B550A-363D-11E5-9242-09173F13E4C5