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Namespace Prefixes

PrefixIRI
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dctermshttp://purl.org/dc/terms/
n7http://linked.opendata.cz/resource/drugbank/drug/DB06803/identifier/pharmgkb/
n4http://linked.opendata.cz/resource/drugbank/drug/DB06803/identifier/wikipedia/
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n12http://linked.opendata.cz/resource/drugbank/drug/DB06803/identifier/pubchem-substance/
n13http://linked.opendata.cz/resource/drugbank/drug/DB06803/identifier/kegg-drug/
n9http://bio2rdf.org/drugbank:
n16http://linked.opendata.cz/resource/drugbank/drug/DB06803/identifier/drugbank/
n11http://www.drugs.com/cons/
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n19http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
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n6http://linked.opendata.cz/resource/drugbank/property/
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xsdhhttp://www.w3.org/2001/XMLSchema#
n18http://linked.opendata.cz/resource/atc/
n17http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB06803
rdf:type
n5:Drug
n5:description
Niclosamide is used for the treatment of most tapeworm infections. Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad range of diseases. Over 1 billion people are infected with intestinal nematodes, and many millions are infected with filarial nematodes, flukes, and tapeworms. They are an even greater problem in domestic animals.
n5:generalReferences
# Rosenthal Philip J, "Chapter 53. Clinical Pharmacology of the Antihelminthic Drugs" (Chapter). Katzung BG: Basic & Clinical Pharmacology, 11e: "http://www.accessmedicine.com/content.aspx?aID=4516635":http://www.accessmedicine.com/content.aspx?aID=4516635. # 2010. Detailed Drug Information for the Consumerâ„¢. Greenwood Village, CO. Thomson Reuters. ISBN-10: 1-56363-575-5. ISSN: 0740-4174. STAT!Ref Online Electronic Medical Library.
n5:group
approved
n5:indication
For the treatment of tapeworm and intestinal fluke infections: Taenia saginata (Beef Tapeworm), Taenia solium (Pork Tapeworm), Diphyllobothrium latum (Fish Tapeworm), Fasciolopsis buski (large intestinal fluke). Niclosamide is also used as a molluscicide in the control of schistosomiasis.
owl:sameAs
n9:DB06803 n19:DB06803
dcterms:title
Niclosamide
adms:identifier
n4:Niclosamide n7:PA165958408 n12:99443295 n13:D00436 n14:4477 n15:4322 n16:DB06803
n5:mechanismOfAction
Niclosamide works by killing tapeworms on contact. Adult worms (but not ova) are rapidly killed, presumably due to uncoupling of oxidative phosphorylation or stimulation of ATPase activity. The killed worms are then passed in the stool or sometimes destroyed in the intestine. Niclosamide may work as a molluscicide by binding to and damaging DNA.
n5:synonym
Niclocide
n5:toxicity
Infrequent, mild, and transitory adverse events include nausea, vomiting, diarrhea, and abdominal discomfort.
n5:synthesisReference
"DrugSyn.org":http://www.drugsyn.org/Niclosamide.htm
foaf:page
n11:niclosamide.html
n5:IUPAC-Name
n6:271B54DC-363D-11E5-9242-09173F13E4C5
n5:InChI
n6:271B54E2-363D-11E5-9242-09173F13E4C5
n5:Molecular-Formula
n6:271B54E1-363D-11E5-9242-09173F13E4C5
n5:Molecular-Weight
n6:271B54DE-363D-11E5-9242-09173F13E4C5
n5:Monoisotopic-Weight
n6:271B54DF-363D-11E5-9242-09173F13E4C5
n5:SMILES
n6:271B54E0-363D-11E5-9242-09173F13E4C5
n5:Water-Solubility
n6:271B54DA-363D-11E5-9242-09173F13E4C5 n6:271B54F2-363D-11E5-9242-09173F13E4C5
n5:logP
n6:271B54DB-363D-11E5-9242-09173F13E4C5 n6:271B54D8-363D-11E5-9242-09173F13E4C5
n5:logS
n6:271B54D9-363D-11E5-9242-09173F13E4C5
n17:hasATCCode
n18:P02DA01
n5:H-Bond-Acceptor-Count
n6:271B54E8-363D-11E5-9242-09173F13E4C5
n5:H-Bond-Donor-Count
n6:271B54E9-363D-11E5-9242-09173F13E4C5
n5:InChIKey
n6:271B54E3-363D-11E5-9242-09173F13E4C5
n5:Polar-Surface-Area--PSA-
n6:271B54E4-363D-11E5-9242-09173F13E4C5
n5:Polarizability
n6:271B54E6-363D-11E5-9242-09173F13E4C5
n5:Refractivity
n6:271B54E5-363D-11E5-9242-09173F13E4C5
n5:Rotatable-Bond-Count
n6:271B54E7-363D-11E5-9242-09173F13E4C5
n5:absorption
Niclosamide appears to be minimally absorbed from the gastrointestinal tract—neither the drug nor its metabolites have been recovered from the blood or urine.
n5:affectedOrganism
Helminthic Microorganisms
n5:casRegistryNumber
50-65-7
n5:Bioavailability
n6:271B54EE-363D-11E5-9242-09173F13E4C5
n5:Ghose-Filter
n6:271B54F0-363D-11E5-9242-09173F13E4C5
n5:MDDR-Like-Rule
n6:271B54F1-363D-11E5-9242-09173F13E4C5
n5:Melting-Point
n6:271B54F3-363D-11E5-9242-09173F13E4C5
n5:Number-of-Rings
n6:271B54ED-363D-11E5-9242-09173F13E4C5
n5:Physiological-Charge
n6:271B54EC-363D-11E5-9242-09173F13E4C5
n5:Rule-of-Five
n6:271B54EF-363D-11E5-9242-09173F13E4C5
n5:Traditional-IUPAC-Name
n6:271B54DD-363D-11E5-9242-09173F13E4C5
n5:pKa--strongest-acidic-
n6:271B54EA-363D-11E5-9242-09173F13E4C5
n5:pKa--strongest-basic-
n6:271B54EB-363D-11E5-9242-09173F13E4C5