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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n13http://linked.opendata.cz/resource/drugbank/drug/DB06723/identifier/drugbank/
n10http://linked.opendata.cz/resource/AHFS/
n5http://linked.opendata.cz/resource/drugbank/dosage/
n7http://bio2rdf.org/drugbank:
admshttp://www.w3.org/ns/adms#
n11http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n9http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB06723
rdf:type
n3:Drug
n3:description
Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects.
n3:dosage
n5:271B5156-363D-11E5-9242-09173F13E4C5 n5:271B5154-363D-11E5-9242-09173F13E4C5 n5:271B5155-363D-11E5-9242-09173F13E4C5
n3:group
approved
n3:indication
For relief of heartburn and acid indigestion.
owl:sameAs
n7:DB06723 n11:DB06723
dcterms:title
Aluminum hydroxide
adms:identifier
n13:DB06723
n3:mechanismOfAction
Aluminum hydroxide is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. Aluminum hydroxide is slowly solubilized in the stomach and reacts with hydrochloric acid to form aluminum chloride and water. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO<sub>3</sub><sup>-</sup>) and prostaglandins.
n3:routeOfElimination
Absorbed aluminum chloride is rapidly eliminated by the kidneys in patients with normal renal function.
n3:synonym
Aluminum hydroxide Aluminiumhydroxid Al(OH)3
n9:hasAHFSCode
n10:56-04
n3:synthesisReference
Richard H. Goheen, William A. Nigro, Paul J. The, "Process for producing aluminum hydroxide of improved whiteness." U.S. Patent US4915930, issued November, 1933.
n3:IUPAC-Name
n4:271B5158-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B515E-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B515D-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B515A-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B515B-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B515C-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B5157-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n4:271B5164-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B5165-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B515F-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B5160-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B5162-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B5161-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B5163-363D-11E5-9242-09173F13E4C5
n3:absorption
Approximately 17-30% of the aluminum chloride formed is absorbed.
n3:category
n3:Bioavailability
n4:271B516A-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B516C-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B516D-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B5169-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B5168-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B516B-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B5159-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B5166-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B5167-363D-11E5-9242-09173F13E4C5