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Namespace Prefixes

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Statements

Subject Item
n2:DB06689
rdf:type
n6:Drug
n6:description
Ethanolamine Oleate is a mild sclerosing agent. It is composed of ethanolamine, a basic substance, which when combined with oleic acid forms a clear, straw to pale yellow colored, deliquescent oleate.
n6:dosage
n12:271B4E1B-363D-11E5-9242-09173F13E4C5
n6:generalReferences
# NOORDIJK JA: [Monoethanolamine oleate.] Ned Tijdschr Geneeskd. 1950 Apr 22;94(16):1110-1. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15416877 # Howard ER, Stamatakis JD, Mowat AP: Management of esophageal varices in children by injection sclerotherapy. J Pediatr Surg. 1984 Feb;19(1):2-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/6607986 # PACCA ML: [Antihyaluronidase activity of monoethanolamine oleate.] Boll Soc Ital Biol Sper. 1951 Mar-Apr;27(4):576-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14869471 # Zuberi BF, Baloch Q: Comparison of endoscopic variceal sclerotherapy alone and in combination with octreotide in controlling acute variceal hemorrhage and early rebleeding in patients with low-risk cirrhosis. Am J Gastroenterol. 2000 Mar;95(3):768-71. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10710072 # VOIGT J: [Allergy to varex (monoethanolamine oleate).] Ugeskr Laeger. 1954 Mar 25;116(12):452-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/13169341 # Meirelles-Santos JO, Carvalho AF Jr, Callejas-Neto F, Magna LA, Yamanaka A, Zeitune JM, Brandalise NA, Ferraz JG: Absolute ethanol and 5% ethanolamine oleate are comparable for sclerotherapy of esophageal varices. Gastrointest Endosc. 2000 May;51(5):573-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10805844 # Masaki M, Mitsuhashi H, Kondo Y, Suzuki S, Wada T: [Effects of embolizing agent (ethanolamine oleate; EO) on esophageal varices with special reference to endothelial injury] Nippon Shokakibyo Gakkai Zasshi. 1984 Jun;81(6):1491. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/6471550 # Seidman E, Weber AM, Morin CL, Ethier R, Lamarche JB, Guerguerian AJ, Geoffroy G, Roy CC: Spinal cord paralysis following sclerotherapy for esophageal varices. Hepatology. 1984 Sep-Oct;4(5):950-4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/6332769 # Takuma Y, Nouso K, Takayama H, Makino Y, Saito S, Tanaka S, Ogata M, Ohta T, Kubota J, Iwamuro M: Gastric ulcer after prophylactic balloon-occluded retrograde transvenous obliteration. J Gastroenterol. 2007 Mar;42(3):257-60. Epub 2007 Mar 30. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17380286 # VOIGT J: [Fatal allergic shock after injection of Varex (monoethanolamine-oleate). On the risks of injection treatment.] Ugeskr Laeger. 1963 Jun 21;125:896-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/13997698 # Yamamoto K, Sakaguchi H, Anai H, Tanaka T, Morimoto K, Kichikawa K, Uchida H: Sclerotherapy for simple cysts with use of ethanolamine oleate: preliminary experience. Cardiovasc Intervent Radiol. 2005 Nov-Dec;28(6):751-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16132390 # Kang JH, Kambayashi J, Sakon M, Shiozaki H, Ogawa Y, Ohshiro T, Mori T: Mechanism of the haemostatic effect of ethanolamine oleate in the injection sclerotherapy for oesophageal varices. Br J Surg. 1987 Jan;74(1):50-3. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/3828735
n6:group
approved
n6:indication
For the treatment of patients with esophageal varices that have recently bled, to prevent rebleeding.
owl:sameAs
n15:DB06689 n21:DB06689
dcterms:title
Ethanolamine Oleate
adms:identifier
n4:5282489 n5:99443246 n8:4445632 n9:PA164746758 n10:Monoethanolamine_oleate n11:67871-479-06 n13:DB06689 n16:D02276
n6:mechanismOfAction
The oleic acid component of ethanolamine oleate is responsible for the inflammatory response, and may also activate coagulation in vivo by release of tissue factor and activation of Hageman factor. The ethanolamine component, however, may inhibit fibrin clot formation by chelating calcium, so that a procoagulant action of ethanolamine oleate has not been demonstrated.
n6:packager
n18:271B4E19-363D-11E5-9242-09173F13E4C5 n18:271B4E18-363D-11E5-9242-09173F13E4C5
n6:synonym
Ethanolamine oleate beta-Hydroxyethylammonium oleate Ethamolin Oldamin Monoethanolamine oleate
n6:toxicity
The minimum lethal dose administered intravenously to rabbits is 130 mg/kg. Overdosage can result in severe intramural necrosis of the esophagus. Complications resulting from such overdosage have resulted in death. LD50 (intravenous) in rats is 156 mg/kg. LD50 (intravenous) in dogs is 175 mg/kg.
n22:hasConcept
n23:M0103493
foaf:page
n20:ethanolamine-oleate.html n24:ethamolin.htm
n6:IUPAC-Name
n7:271B4E1D-363D-11E5-9242-09173F13E4C5
n6:InChI
n7:271B4E23-363D-11E5-9242-09173F13E4C5
n6:Molecular-Formula
n7:271B4E22-363D-11E5-9242-09173F13E4C5
n6:Molecular-Weight
n7:271B4E1F-363D-11E5-9242-09173F13E4C5
n6:Monoisotopic-Weight
n7:271B4E20-363D-11E5-9242-09173F13E4C5
n6:SMILES
n7:271B4E21-363D-11E5-9242-09173F13E4C5
n6:logP
n7:271B4E1C-363D-11E5-9242-09173F13E4C5
n26:hasATCCode
n27:C05BB01
n6:H-Bond-Acceptor-Count
n7:271B4E29-363D-11E5-9242-09173F13E4C5
n6:H-Bond-Donor-Count
n7:271B4E2A-363D-11E5-9242-09173F13E4C5
n6:InChIKey
n7:271B4E24-363D-11E5-9242-09173F13E4C5
n6:Polar-Surface-Area--PSA-
n7:271B4E25-363D-11E5-9242-09173F13E4C5
n6:Polarizability
n7:271B4E27-363D-11E5-9242-09173F13E4C5
n6:Refractivity
n7:271B4E26-363D-11E5-9242-09173F13E4C5
n6:Rotatable-Bond-Count
n7:271B4E28-363D-11E5-9242-09173F13E4C5
n6:absorption
After injection into an esophageal varix, ethanolamine oleate is cleared from the injection site within five minutes via the portal vein. Some of the medication also flows into the azygos vein through the periesophageal vein if more than 20 mL is injected.
n6:affectedOrganism
Humans and other mammals
n6:casRegistryNumber
2272-11-9
n6:category
n6:containedIn
n17:271B4E1A-363D-11E5-9242-09173F13E4C5
n6:Bioavailability
n7:271B4E2E-363D-11E5-9242-09173F13E4C5
n6:Ghose-Filter
n7:271B4E30-363D-11E5-9242-09173F13E4C5
n6:MDDR-Like-Rule
n7:271B4E31-363D-11E5-9242-09173F13E4C5
n6:Number-of-Rings
n7:271B4E2D-363D-11E5-9242-09173F13E4C5
n6:Physiological-Charge
n7:271B4E2C-363D-11E5-9242-09173F13E4C5
n6:Rule-of-Five
n7:271B4E2F-363D-11E5-9242-09173F13E4C5
n6:Traditional-IUPAC-Name
n7:271B4E1E-363D-11E5-9242-09173F13E4C5
n6:pKa--strongest-acidic-
n7:271B4E2B-363D-11E5-9242-09173F13E4C5