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Namespace Prefixes

PrefixIRI
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Statements

Subject Item
n2:DB05875
rdf:type
n3:Drug
n3:description
Homspera is a generic name used by the Company to describe the synthetic peptide Sar9, Met (O2)11-Substance P. Sar9, Met (O2)11-Substance P is an analog of the naturally occurring human neuropeptide Substance P, which can be found throughout the body, including in the airways of humans and many other species. All of the Company's research and development efforts are in early, pre-clinical stages and Homspera, also known as Viprovex and Radilex, has only undergone exploratory studies to evaluate its biological activity in small animals.
n3:generalReferences
# Grimsholm O, Rantapaa-Dahlqvist S, Dalen T, Forsgren S: Observations favouring the occurrence of local production and marked effects of bombesin/gastrin-releasing peptide in the synovial tissue of the human knee joint - Comparisons with substance P and the NK-1 receptor. Neuropeptides. 2008 Apr;42(2):133-45. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18289674 # Rothstein RD, Johnson E, Ouyang A: Substance P: mechanism of action and receptor distribution at the feline ileocecal sphincter region. Am J Physiol. 1989 Sep;257(3 Pt 1):G447-53. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2476938 # Sequence Information "Link":http://www.abcam.com/Substance-P-protein-ab9608.html
n3:group
investigational
n3:indication
Investigated for use/treatment in acute respiratory distress syndrome (ARDS) and viral infection.
owl:sameAs
n10:DB05875
dcterms:title
substance P
adms:identifier
n5:36511 n6:Substance_P n7:DB05875
n3:mechanismOfAction
The endogenous receptor for Substance P is neurokinin 1 receptor (NK1-receptor, NK1R). It belongs to the tachykinin receptor sub-family of GPCRs. Substance P has been shown to stimulate cellular growth in cell culture [2], and it was shown that Substance P could promote wound healing of non-healing ulcers in humans. [3] It has also been shown to reverse diabetes in mice.
n3:Molecular-Formula
n8:271B4861-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n8:271B4860-363D-11E5-9242-09173F13E4C5