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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n8http://linked.opendata.cz/resource/drugbank/drug/DB05871/identifier/drugbank/
n11http://bio2rdf.org/drugbank:
n6http://linked.opendata.cz/resource/drugbank/drug/DB05871/identifier/chemspider/
admshttp://www.w3.org/ns/adms#
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n9http://linked.opendata.cz/resource/drugbank/drug/DB05871/identifier/pubchem-compound/

Statements

Subject Item
n2:DB05871
rdf:type
n3:Drug
n3:description
UC-781 is a thiocarboxanilide non-nucleoside reverse transcriptase inhibitor (NNRTI). It is a topical microbicide targeted against the AIDS virus.
n3:generalReferences
# Patton DL, Sweeney YT, Balkus JE, Rohan LC, Moncla BJ, Parniak MA, Hillier SL: Preclinical safety assessments of UC781 anti-human immunodeficiency virus topical microbicide formulations. Antimicrob Agents Chemother. 2007 May;51(5):1608-15. Epub 2007 Mar 12. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17353240 # Hossain MM, Parniak MA: In vitro microbicidal activity of the nonnucleoside reverse transcriptase inhibitor (NNRTI) UC781 against NNRTI-resistant human immunodeficiency virus type 1. J Virol. 2006 May;80(9):4440-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16611904
n3:group
investigational
n3:indication
Investigated for use/treatment in HIV infection.
owl:sameAs
n11:DB05871
dcterms:title
UC-781
adms:identifier
n6:2272425 n8:DB05871 n9:3000926
n3:mechanismOfAction
UC-781 is an HIV non-nucleoside reverse transcriptase inhibitor (NNRTI) that has shown in vitro to be very active specifically against HIV-1. UC-781 exhibits synergy with the NRTI zidovudine in vitro.[12] The combination of UC-781 and another candidate microbicide, cellulose acetate 1,2-benzenedicarboxylate, resulted in effective synergy for inhibition of HIV-1 in vitro and in peripheral blood mononuclear cells
n3:IUPAC-Name
n4:271B484A-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B4850-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B484F-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B484C-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B484D-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B484E-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B4848-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B4849-363D-11E5-9242-09173F13E4C5 n4:271B4846-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B4847-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n4:271B4856-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B4857-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B4851-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B4852-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B4854-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B4853-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B4855-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n4:271B485C-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B485E-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B485F-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B485B-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B485A-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B485D-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B484B-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B4858-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B4859-363D-11E5-9242-09173F13E4C5