This HTML5 document contains 37 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n10http://linked.opendata.cz/resource/drugbank/drug/DB05869/identifier/pubchem-compound/
n6http://bio2rdf.org/drugbank:
n9http://linked.opendata.cz/resource/drugbank/drug/DB05869/identifier/drugbank/
admshttp://www.w3.org/ns/adms#
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n11http://linked.opendata.cz/resource/drugbank/drug/DB05869/identifier/chemspider/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#

Statements

Subject Item
n2:DB05869
rdf:type
n3:Drug
n3:description
CTI-01 (ethyl pyruvate) is a novel anti-inflammatory agent for the treatment of critical inflammatory conditions. CTI-01 shows a potent anti-inflammatory and tissue protection activity in multiple animal models of disease including pancreatitis, ischemia-reperfusion injury, sepsis, renal injury and endotoxemia.
n3:generalReferences
# Kou QY, Guan XD: [Effect of ethyl pyruvate on indices of tissue oxygenation and perfusion in dogs with septic shock] Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2008 Jan;20(1):34-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18199399 # Cheng BQ, Liu CT, Li WJ, Fan W, Zhong N, Zhang Y, Jia XQ, Zhang SZ: Ethyl pyruvate improves survival and ameliorates distant organ injury in rats with severe acute pancreatitis. Pancreas. 2007 Oct;35(3):256-61. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17895847
n3:group
investigational
n3:indication
Investigated for use/treatment in burns and burn infections, cardiac surgery, inflammatory disorders (unspecified), ischemic reperfusion injury, and sepsis and septicemia.
owl:sameAs
n6:DB05869
dcterms:title
CTI-01
adms:identifier
n9:DB05869 n10:12041 n11:11544
n3:mechanismOfAction
CTI-01 inhibits the systemic release of cytokines, such as TNF-alpha and HMGB1, which promote the body's inflammatory response. The over-expression of these cytokines has been linked to diseases that occur in critical care settings, such as severe organ damage following cardiopulmonary bypass (CPB) and post-operative ileus following abdominal surgery.
n3:IUPAC-Name
n4:271B4830-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B4836-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B4835-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B4832-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B4833-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B4834-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B482E-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B482C-363D-11E5-9242-09173F13E4C5 n4:271B482F-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B482D-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n4:271B483C-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B483D-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B4837-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B4838-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B483A-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B4839-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B483B-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n4:271B4842-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B4844-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B4845-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B4841-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B4840-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B4843-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B4831-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B483E-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B483F-363D-11E5-9242-09173F13E4C5