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Namespace Prefixes

PrefixIRI
n9http://linked.opendata.cz/resource/drugbank/drug/DB05804/identifier/drugbank/
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n11http://linked.opendata.cz/resource/drugbank/drug/DB05804/identifier/chemspider/
n6http://bio2rdf.org/drugbank:
admshttp://www.w3.org/ns/adms#
n8http://linked.opendata.cz/resource/drugbank/drug/DB05804/identifier/wikipedia/
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owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n4http://linked.opendata.cz/resource/drugbank/property/
n10http://linked.opendata.cz/resource/drugbank/drug/DB05804/identifier/pubchem-compound/
xsdhhttp://www.w3.org/2001/XMLSchema#

Statements

Subject Item
n2:DB05804
rdf:type
n3:Drug
n3:description
DHEA sulfate is the major steroid of the fetal adrenal. DHEA-S is the principal adrenal androgen and is secreted together with cortisol under the control of ACTH and prolactin. DHEA-S is elevated with hyperprolactinemia.
n3:generalReferences
# Altman R, Motton DD, Kota RS, Rutledge JC: Inhibition of vascular inflammation by dehydroepiandrosterone sulfate in human aortic endothelial cells: Roles of PPARalpha and NF-kappaB. Vascul Pharmacol. 2007 Dec 15;. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18255343 # Rabijewski M, Papierska L, Kozakowski J, Zgliczynski W: [The relationship between androgens concentrations (testosterone and dehydroepiandrosterone sulfate) and metabolic syndrome in non-obese elderly men.] Endokrynol Pol. 2007;58(6):496-504. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18205106 # Geyer J, Doring B, Meerkamp K, Ugele B, Bakhiya N, Fernandes CF, Godoy JR, Glatt H, Petzinger E: Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6). J Biol Chem. 2007 Jul 6;282(27):19728-41. Epub 2007 May 9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17491011
n3:group
investigational
n3:indication
Investigated for use/treatment in asthma and burns and burn infections.
owl:sameAs
n6:DB05804
dcterms:title
dehydroepiandrosterone sulfate
adms:identifier
n8:Dehydroepiandrosterone n9:DB05804 n10:12594 n11:12074
n3:mechanismOfAction
The low levels of dehydroepiandrosterone sulfate(DHEA-S)is associated with unfavorable levels of several strong cardiovascular disease risk factors, such as lipids and blood pleasure, which are components of the metabolic syndrome, and insulin levels. DHEA-S deficiency is risk factors of obesity and insulin resistance, but it is not clear, whether this possible influence is independent.
n3:IUPAC-Name
n4:271B46F5-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B46FB-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B46FA-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B46F7-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B46F8-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B46F9-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B46F3-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B46F4-363D-11E5-9242-09173F13E4C5 n4:271B46F1-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B46F2-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n4:271B4701-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B4702-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B46FC-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B46FD-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B46FF-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B46FE-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B4700-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n4:271B4707-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B4709-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B470A-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B4706-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B4705-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B4708-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B46F6-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B4703-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B4704-363D-11E5-9242-09173F13E4C5