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Namespace Prefixes

PrefixIRI
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Statements

Subject Item
n2:DB05794
rdf:type
n3:Drug
n3:description
Recombinant human relaxin is a hormone produced during pregnancy that facilitates the birth process by causing a softening and lengthening of the cervix and the pubic symphysis (the place where the pubic bones come together).It is a heterodimer protein secreted by the corpus luteum and placenta during pregnancy.
n3:generalReferences
# Debrah DO, Novak J, Matthews JE, Ramirez RJ, Shroff SG, Conrad KP: Relaxin is essential for systemic vasodilation and increased global arterial compliance during early pregnancy in conscious rats. Endocrinology. 2006 Nov;147(11):5126-31. Epub 2006 Jul 27. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16873529 # Nistri S, Cinci L, Perna AM, Masini E, Mastroianni R, Bani D: Relaxin induces mast cell inhibition and reduces ventricular arrhythmias in a swine model of acute myocardial infarction. Pharmacol Res. 2007 Nov 9;. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18068999
n3:group
investigational
n3:indication
Investigated for use/treatment in cardiovascular disorders, congestive heart failure, infertility, peripheral vascular disease, and scleroderma.
owl:sameAs
n11:DB05794
dcterms:title
recombinant human relaxin
adms:identifier
n6:Relaxin n7:DB05794 n8:19261
n3:mechanismOfAction
Recombinant human relaxin inhibits contractions of the uterus and may play a role in timing of delivery. Relaxin works by simultaneously cutting collagen production and increasing collagen breakdown.
n3:Molecular-Formula
n4:271B46BC-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B46BB-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals