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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n8http://linked.opendata.cz/resource/drugbank/drug/DB05479/identifier/chemspider/
n6http://bio2rdf.org/drugbank:
n11http://linked.opendata.cz/resource/drugbank/drug/DB05479/identifier/pubchem-compound/
admshttp://www.w3.org/ns/adms#
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n10http://linked.opendata.cz/resource/drugbank/drug/DB05479/identifier/drugbank/
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#

Statements

Subject Item
n2:DB05479
rdf:type
n3:Drug
n3:description
CZEN-002 is a novel, non-azole anti-fungal synthetic octapeptide, derived from alpha-Melanocyte-Stimulating Hormone (a-MSH). CZEN-002 modulates inflammatory and immune responses. It has also been shown to kill Candida albicans (C. albicans), a single-celled fungal organism that causes a variety of infections, including vaginitis. This organism can invade tissues and produce fatal infections in individuals with compromised immune systems such as those suffering from HIV/AIDS or undergoing organ or bone transplants. The antimicrobial activity of CZEN-002 is unique in that it does not depend on direct damage to the microbial membrane. It appears that CZEN-002 works on a receptor in yeast that has yet to be identified. Studies attempting to understand the candidacidal activity of derivatives of alpha-MSH have focused on the alpha-MSH amino acid sequence (6-13), which contains the invariant core sequence His-Phe-Arg-Trp (6-9) that is important for binding to the known melanocortin receptors. A second focus was on the sequence Lys-Pro-Val (11-13) that is known to be important for antimicrobial activity.
n3:generalReferences
# Csato M, Kenderessy AS, Dobozy A: Enhancement of Candida albicans killing activity of separated human epidermal cells by alpha-melanocyte stimulating hormone. Br J Dermatol. 1989 Jul;121(1):145-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2547421
n3:group
investigational
n3:indication
Investigated for use/treatment in candidiasis and vaginitis.
owl:sameAs
n6:DB05479
dcterms:title
CZEN 002
adms:identifier
n8:17286474 n10:DB05479 n11:16129664
n3:mechanismOfAction
The antimicrobial activity of CZEN-002 is unique in that it does not depend on direct damage to the microbial membrane. It appears that CZEN-002 works on a receptor in yeast that has yet to be identified. Studies attempting to understand the candidacidal activity of derivatives of alpha-MSH have focused on the alpha-MSH amino acid sequence (6-13), which contains the invariant core sequence His-Phe-Arg-Trp (6-9) that is important for binding to the known melanocortin receptors. A second focus was on the sequence Lys-Pro-Val (11-13) that is known to be important for antimicrobial activity.
n3:IUPAC-Name
n4:271B44DC-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B44E2-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B44E1-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B44DE-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B44DF-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B44E0-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B44DA-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B44DB-363D-11E5-9242-09173F13E4C5 n4:271B44D8-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B44D9-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n4:271B44E8-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B44E9-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B44E3-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B44E4-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B44E6-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B44E5-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B44E7-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Yeast and other fungi Fungi
n3:Bioavailability
n4:271B44EE-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B44F0-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B44F1-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B44ED-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B44EC-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B44EF-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B44DD-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B44EA-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B44EB-363D-11E5-9242-09173F13E4C5