This HTML5 document contains 36 embedded RDF statements represented using HTML+Microdata notation.

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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n12http://linked.opendata.cz/resource/drugbank/drug/DB05171/identifier/pubchem-substance/
n9http://linked.opendata.cz/resource/drugbank/drug/DB05171/identifier/drugbank/
n7http://bio2rdf.org/drugbank:
n11http://linked.opendata.cz/resource/drugbank/drug/DB05171/identifier/chemspider/
admshttp://www.w3.org/ns/adms#
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n10http://linked.opendata.cz/resource/drugbank/drug/DB05171/identifier/pubchem-compound/

Statements

Subject Item
n2:DB05171
rdf:type
n3:Drug
n3:description
E2012 is a gamma secretase modulator that is being evaluated as a potential new treatment for Alzheimer's disease.
n3:group
investigational
n3:indication
Investigated for use/treatment in alzheimer's disease.
owl:sameAs
n7:DB05171
dcterms:title
E2012
adms:identifier
n9:DB05171 n10:6421261 n11:4926802 n12:10361696
n3:mechanismOfAction
Gamma secretase plays a role in the production of beta-amyloid, a major component of plaque in the brain, which is thought to be a cause of Alzheimer's disease. E2012 is a new chemical entity discovered by Eisai and, in preclinical (laboratory) research, has shown some potential to reduce the production of beta-amyloid by modulating the function of gamma secretase.
n3:IUPAC-Name
n4:271B64E4-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B64EA-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B64E9-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B64E6-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B64E7-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B64E8-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B64E2-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B64E0-363D-11E5-9242-09173F13E4C5 n4:271B64E3-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B64E1-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n4:271B64F0-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B64F1-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B64EB-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B64EC-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B64EE-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B64ED-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B64EF-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n4:271B64F5-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B64F7-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B64F8-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B64F4-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B64F3-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B64F6-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B64E5-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B64F2-363D-11E5-9242-09173F13E4C5