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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n7http://linked.opendata.cz/resource/drugbank/drug/DB05154/identifier/pubchem-compound/
n12http://bio2rdf.org/drugbank:
n8http://linked.opendata.cz/resource/drugbank/drug/DB05154/identifier/pubchem-substance/
admshttp://www.w3.org/ns/adms#
n10http://linked.opendata.cz/resource/drugbank/drug/DB05154/identifier/drugbank/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n9http://linked.opendata.cz/resource/drugbank/drug/DB05154/identifier/chemspider/

Statements

Subject Item
n2:DB05154
rdf:type
n3:Drug
n3:description
PA-824 is a nitroimidazole, a class of novel anti-bacterial agents. As a potential TB therapy, it has many attractive characteristics - most notably its novel mechanism of action, its activity in vitro against all tested drug-resistant clinical isolates, and its activity as both a potent bactericidal and a sterilizing agent in mice. In addition, the compound shows no evidence of mutagenicity in a standard battery of genotoxicity studies, no significant cytochrome P450 interactions, and no significant activity against a broad range of Gram-positive and Gram-negative bacteria.
n3:group
investigational
n3:indication
Investigated for use/treatment in bacterial infection and tuberculosis.
owl:sameAs
n12:DB05154
dcterms:title
PA824
adms:identifier
n7:456199 n8:11568219 n9:401693 n10:DB05154
n3:mechanismOfAction
Although the mechanism of action of PA824 is not well understood, it appears that the compound functions as a prodrug requiring reductive activation of the aromatic nitro group that is mediated, at least in part, by a specific glucose-6-phosphate dehydrogenase or its deazaflavin cofactor.
n3:IUPAC-Name
n4:271B64CB-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B64D1-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B64D0-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B64CD-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B64CE-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B64CF-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B64C9-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B64C7-363D-11E5-9242-09173F13E4C5 n4:271B64CA-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B64C8-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n4:271B64D7-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B64D8-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B64D2-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B64D3-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B64D5-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B64D4-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B64D6-363D-11E5-9242-09173F13E4C5
n3:casRegistryNumber
187235-37-6
n3:Bioavailability
n4:271B64DC-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B64DE-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B64DF-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B64DB-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B64DA-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B64DD-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B64CC-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B64D9-363D-11E5-9242-09173F13E4C5