This HTML5 document contains 43 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n8http://linked.opendata.cz/resource/drugbank/drug/DB05105/identifier/pdb/
n9http://linked.opendata.cz/resource/drugbank/drug/DB05105/identifier/pubchem-compound/
n6http://linked.opendata.cz/resource/drugbank/drug/DB05105/identifier/pubchem-substance/
n11http://linked.opendata.cz/resource/drugbank/drug/DB05105/identifier/drugbank/
n13http://bio2rdf.org/drugbank:
admshttp://www.w3.org/ns/adms#
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n10http://linked.opendata.cz/resource/drugbank/drug/DB05105/identifier/chemspider/
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n15http://linked.opendata.cz/ontology/sukl/drug/
n16http://linked.opendata.cz/resource/atc/
n7http://linked.opendata.cz/resource/drugbank/drug/DB05105/identifier/wikipedia/

Statements

Subject Item
n2:DB05105
rdf:type
n3:Drug
n3:description
Pleconaril is an antiviral drug being developed by Schering-Plough for prevention of asthma exacerbations and common cold symptoms in asthmatic subjects exposed to picornavirus respiratory infections. Although the formulation used by Schering-Plough is a nasal spray, pleconaril is orally bioavailable, and is active against viruses in the Picornaviridae family, including Enterovirus and Rhinovirus.
n3:generalReferences
# Webster AD: Pleconaril--an advance in the treatment of enteroviral infection in immuno-compromised patients. J Clin Virol. 2005 Jan;32(1):1-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15571999 # Florea NR, Maglio D, Nicolau DP: Pleconaril, a novel antipicornaviral agent. Pharmacotherapy. 2003 Mar;23(3):339-48. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12627933
n3:group
investigational
n3:indication
Investigated for use/treatment in upper respiratory infection.
owl:sameAs
n13:DB05105
dcterms:title
Pleconaril
adms:identifier
n6:12014826 n7:Pleconaril n8:W11 n9:1684 n10:1621 n11:DB05105
n3:mechanismOfAction
Pleconaril binds to a hydrophobic pocket in viral protein 1, the major protein which comprises the capsid (the outer "shell") of picornaviruses. In enteroviruses, this prevents the virus from exposing its RNA, and in rhinoviruses it also prevents the virus from attaching itself to the host cell.
n3:proteinBinding
>99%
n3:IUPAC-Name
n4:271B63FA-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B6400-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B63FF-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B63FC-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B63FD-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B63FE-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B63F8-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B63F6-363D-11E5-9242-09173F13E4C5 n4:271B63F9-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B63F7-363D-11E5-9242-09173F13E4C5
n15:hasATCCode
n16:J05AX06
n3:H-Bond-Acceptor-Count
n4:271B6406-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B6407-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B6401-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B6402-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B6404-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B6403-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B6405-363D-11E5-9242-09173F13E4C5
n3:absorption
70% (oral)
n3:casRegistryNumber
153168-05-9
n3:Bioavailability
n4:271B640B-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B640D-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B640E-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B640A-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B6409-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B640C-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B63FB-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B6408-363D-11E5-9242-09173F13E4C5