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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
n10http://linked.opendata.cz/resource/drugbank/drug/DB05095/identifier/drugbank/
dctermshttp://purl.org/dc/terms/
n13http://linked.opendata.cz/resource/drugbank/drug/DB05095/identifier/chemspider/
n6http://bio2rdf.org/drugbank:
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owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n4http://linked.opendata.cz/resource/drugbank/property/
n12http://linked.opendata.cz/resource/drugbank/drug/DB05095/identifier/bindingdb/
n11http://linked.opendata.cz/resource/drugbank/drug/DB05095/identifier/pubchem-compound/
xsdhhttp://www.w3.org/2001/XMLSchema#
n9http://linked.opendata.cz/resource/drugbank/drug/DB05095/identifier/pubchem-substance/

Statements

Subject Item
n2:DB05095
rdf:type
n3:Drug
n3:description
Cimicoxib is a selective COX-2 inhibitor being developed by Affectis as a treatment for depression and schizophrenia. If approved, Cimicoxib would be the first drug in decades to treat depression by a new mechanism of action.
n3:generalReferences
# Chegaev K, Lazzarato L, Tosco P, Cena C, Marini E, Rolando B, Carrupt PA, Fruttero R, Gasco A: NO-donor COX-2 inhibitors. New nitrooxy-substituted 1,5-diarylimidazoles endowed with COX-2 inhibitory and vasodilator properties. J Med Chem. 2007 Apr 5;50(7):1449-57. Epub 2007 Mar 3. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17335184 # Almansa C, Bartroli J, Belloc J, Cavalcanti FL, Ferrando R, Gomez LA, Ramis I, Carceller E, Merlos M, Garcia-Rafanell J: New water-soluble sulfonylphosphoramidic acid derivatives of the COX-2 selective inhibitor cimicoxib. A novel approach to sulfonamide prodrugs. J Med Chem. 2004 Oct 21;47(22):5579-82. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15481993
n3:group
investigational
n3:indication
Investigated for use/treatment in depression.
owl:sameAs
n6:DB05095
dcterms:title
Cimicoxib
adms:identifier
n9:12015453 n10:DB05095 n11:213053 n12:50131593 n13:184745
n3:mechanismOfAction
Depression and schizophrenia are inflammatory diseases. Increased levels of pro-inflammatory cytokines and prostaglandin E (PGE) have repeatedly been described in major depression. COX-2 inhibitors inhibit production of both. Cimicoxib is a selective COX-2 inhibitor. The mechanism by which some COX-2 inhibitors work in depression could be linked to their anti-inflammatory mechanisms.
n3:IUPAC-Name
n4:271B6392-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B6398-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B6397-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B6394-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B6395-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B6396-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B6390-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B638E-363D-11E5-9242-09173F13E4C5 n4:271B6391-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B638F-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n4:271B639E-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B639F-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B6399-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B639A-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B639C-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B639B-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B639D-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
265114-23-6
n3:Bioavailability
n4:271B63A4-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B63A6-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B63A7-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B63A3-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B63A2-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B63A5-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B6393-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B63A0-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B63A1-363D-11E5-9242-09173F13E4C5