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Namespace Prefixes

PrefixIRI
n9http://linked.opendata.cz/resource/drugbank/drug/DB04870/identifier/pubchem-substance/
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n11http://linked.opendata.cz/resource/drugbank/drug/DB04870/identifier/drugbank/
n6http://bio2rdf.org/drugbank:
n8http://linked.opendata.cz/resource/drugbank/drug/DB04870/identifier/chemspider/
admshttp://www.w3.org/ns/adms#
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n10http://linked.opendata.cz/resource/drugbank/drug/DB04870/identifier/wikipedia/
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n12http://linked.opendata.cz/resource/drugbank/drug/DB04870/identifier/pubchem-compound/

Statements

Subject Item
n2:DB04870
rdf:type
n3:Drug
n3:description
Oleoyl-estrone (OE) is a fatty acid ester of estrone. It is a naturally circulating hormone in animals including humans. It was first reported in 1996 to cause a body fat loss effect in rats in the International Journal of Obesity and Related Metabolic Disorders. The animal research has all been conducted by the Nitrogen-Obesity Research Group of the University of Barcelona. The compound was found to potently induce body-fat loss while preserving protein stores in animals which is the ultimate goal of an anti-obesity agent as body protein loss is an undesired but inevitable (to some degree) side effect of fat loss via calorie restriction. [Wikipedia]
n3:generalReferences
# Sanchis D, Balada F, del Mar Grasa M, Virgili J, Peinado J, Monserrat C, Fernandez-Lopez JA, Remesar X, Alemany M: Oleoyl-estrone induces the loss of body fat in rats. Int J Obes Relat Metab Disord. 1996 Jun;20(6):588-94. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8782737 # Salas A, Remesar X, Esteve M: Oleoyl-estrone treatment activates apoptotic mechanisms in white adipose tissue. Life Sci. 2007 Jan 2;80(4):293-8. Epub 2006 Sep 30. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17055002
n3:group
investigational
n3:indication
For the treatment of obesity.
owl:sameAs
n6:DB04870
dcterms:title
Oleoyl estrone
adms:identifier
n8:5293576 n9:12015140 n10:Oleoyl-estrone n11:DB04870 n12:6918373
n3:mechanismOfAction
Based on extensive preclinical studies, it is believed that oleoyl-estrone (OE) works by a dual mechanism of action. Centrally, OE appears to act at the brain's hypothalamus, resetting the body's ponderostat, the “food control center” in the brain that detects and integrates signals that control both appetite and metabolic behavior. Peripherally, OE also causes reduced storage of fat in “white fat” tissue and allows skeletal muscle to use fat as an alternate energy source.
n3:synonym
Estrone 3-oleate Oleoyl-estrone OE
n3:IUPAC-Name
n4:271B5B8E-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B5B94-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B5B93-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B5B90-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B5B91-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B5B92-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B5B8C-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B5B8D-363D-11E5-9242-09173F13E4C5 n4:271B5B8A-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B5B8B-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n4:271B5B9A-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B5B9B-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B5B95-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B5B96-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B5B98-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B5B97-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B5B99-363D-11E5-9242-09173F13E4C5
n3:absorption
Orally available
n3:affectedOrganism
Humans and other mammals
n3:category
n3:Bioavailability
n4:271B5BA0-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B5BA2-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B5BA3-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B5B9F-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B5B9E-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B5BA1-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B5B8F-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B5B9C-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B5B9D-363D-11E5-9242-09173F13E4C5