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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n5http://linked.opendata.cz/resource/drugbank/drug/DB04864/identifier/drugbank/
n13http://bio2rdf.org/drugbank:
n9http://linked.opendata.cz/resource/drugbank/drug/DB04864/identifier/chemspider/
admshttp://www.w3.org/ns/adms#
n14http://linked.opendata.cz/resource/drugbank/drug/DB04864/identifier/wikipedia/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
owlhttp://www.w3.org/2002/07/owl#
n6http://linked.opendata.cz/ontology/drugbank/
n10http://linked.opendata.cz/resource/drugbank/property/
n7http://linked.opendata.cz/resource/drugbank/drug/DB04864/identifier/kegg-compound/
n8http://linked.opendata.cz/resource/drugbank/drug/DB04864/identifier/bindingdb/
xsdhhttp://www.w3.org/2001/XMLSchema#
n15http://linked.opendata.cz/resource/drugbank/drug/DB04864/identifier/pubchem-compound/
n4http://linked.opendata.cz/resource/drugbank/drug/DB04864/identifier/pubchem-substance/

Statements

Subject Item
n2:DB04864
rdf:type
n6:Drug
n6:description
Huperzine A, is a naturally occurring sesquiterpene alkaloid found in the extracts of the firmoss <i>Huperzia serrata</i>. The botanical has been used in China for centuries for the treatment of swelling, fever and blood disorders. Recently in clinical trials in China, it has demonstrated neuroprotective effects. It is currently being investigated as a possible treatment for diseases characterized by neurodegeneration – particularly Alzheimer’s disease. [Wikipedia]
n6:generalReferences
# Li WM, Kan KK, Carlier PR, Pang YP, Han YF: East meets west in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine a. Curr Alzheimer Res. 2007 Sep;4(4):386-96. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17908041
n6:group
investigational
n6:indication
For the treatment of Alzheimer's disease.
owl:sameAs
n13:DB04864
dcterms:title
Huperzine A
adms:identifier
n4:12178 n5:DB04864 n7:C09992 n8:10596 n9:4744649 n14:Huperzine_A n15:5912039
n6:mechanismOfAction
Huperzine A has been found to be an inhibitor of the enzyme acetylcholinesterase. This is the same mechanism of action of pharmaceutical drugs such as galantamine and donepezil used to treat Alzheimer's disease.
n6:synonym
Wilfordine Fordine Huperzine HupA
n6:IUPAC-Name
n10:271B5AEE-363D-11E5-9242-09173F13E4C5
n6:InChI
n10:271B5AF4-363D-11E5-9242-09173F13E4C5
n6:Molecular-Formula
n10:271B5AF3-363D-11E5-9242-09173F13E4C5
n6:Molecular-Weight
n10:271B5AF0-363D-11E5-9242-09173F13E4C5
n6:Monoisotopic-Weight
n10:271B5AF1-363D-11E5-9242-09173F13E4C5
n6:SMILES
n10:271B5AF2-363D-11E5-9242-09173F13E4C5
n6:Water-Solubility
n10:271B5AEC-363D-11E5-9242-09173F13E4C5
n6:logP
n10:271B5AEA-363D-11E5-9242-09173F13E4C5 n10:271B5AED-363D-11E5-9242-09173F13E4C5
n6:logS
n10:271B5AEB-363D-11E5-9242-09173F13E4C5
n6:H-Bond-Acceptor-Count
n10:271B5AFA-363D-11E5-9242-09173F13E4C5
n6:H-Bond-Donor-Count
n10:271B5AFB-363D-11E5-9242-09173F13E4C5
n6:InChIKey
n10:271B5AF5-363D-11E5-9242-09173F13E4C5
n6:Polar-Surface-Area--PSA-
n10:271B5AF6-363D-11E5-9242-09173F13E4C5
n6:Polarizability
n10:271B5AF8-363D-11E5-9242-09173F13E4C5
n6:Refractivity
n10:271B5AF7-363D-11E5-9242-09173F13E4C5
n6:Rotatable-Bond-Count
n10:271B5AF9-363D-11E5-9242-09173F13E4C5
n6:affectedOrganism
Humans and other mammals
n6:casRegistryNumber
102518-79-6
n6:category
n6:Bioavailability
n10:271B5B00-363D-11E5-9242-09173F13E4C5
n6:Ghose-Filter
n10:271B5B02-363D-11E5-9242-09173F13E4C5
n6:MDDR-Like-Rule
n10:271B5B03-363D-11E5-9242-09173F13E4C5
n6:Melting-Point
n10:271B5B04-363D-11E5-9242-09173F13E4C5
n6:Number-of-Rings
n10:271B5AFF-363D-11E5-9242-09173F13E4C5
n6:Physiological-Charge
n10:271B5AFE-363D-11E5-9242-09173F13E4C5
n6:Rule-of-Five
n10:271B5B01-363D-11E5-9242-09173F13E4C5
n6:Traditional-IUPAC-Name
n10:271B5AEF-363D-11E5-9242-09173F13E4C5
n6:pKa--strongest-acidic-
n10:271B5AFC-363D-11E5-9242-09173F13E4C5
n6:pKa--strongest-basic-
n10:271B5AFD-363D-11E5-9242-09173F13E4C5