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Namespace Prefixes

Prefix	IRI
n2	http://linked.opendata.cz/resource/drugbank/drug/
dcterms	http://purl.org/dc/terms/
n8	http://linked.opendata.cz/resource/drugbank/drug/DB04853/identifier/pubchem-compound/
n7	http://linked.opendata.cz/resource/drugbank/drug/DB04853/identifier/kegg-drug/
n13	http://bio2rdf.org/drugbank:
n6	http://linked.opendata.cz/resource/drugbank/drug/DB04853/identifier/pubchem-substance/
n10	http://linked.opendata.cz/resource/drugbank/drug/DB04853/identifier/drugbank/
adms	http://www.w3.org/ns/adms#
rdf	http://www.w3.org/1999/02/22-rdf-syntax-ns#
owl	http://www.w3.org/2002/07/owl#
n3	http://linked.opendata.cz/ontology/drugbank/
n4	http://linked.opendata.cz/resource/drugbank/property/
n9	http://linked.opendata.cz/resource/drugbank/drug/DB04853/identifier/chemspider/
xsdh	http://www.w3.org/2001/XMLSchema#

Statements

Subject Item: n2:DB04853
rdf:type: n3:Drug
n3:description: Binodenoson is a pharmacologic stress agent specific to the only adenosine receptor necessary for increased cardiac blood flow, the A<sub>2A</sub> receptor. This specificity allows Binodenoson to deliver - in a single injection - a more effective dose of medication with fewer side effects than current treatments, which typically require a 15-20 minute infusion.
n3:generalReferences: # Iskandrian AE: A new generation of coronary vasodilators in stress perfusion imaging. Am J Cardiol. 2007 Jun 1;99(11):1619-20. Epub 2007 Apr 18. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17531594 # Barrett RJ, Lamson MJ, Johnson J, Smith WB: Pharmacokinetics and safety of binodenoson after intravenous dose escalation in healthy volunteers. J Nucl Cardiol. 2005 Mar-Apr;12(2):166-71. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15812370
n3:group: investigational
n3:halfLife: 10 ± 4 minutes
n3:indication: For cardiac pharmacologic stress SPECT imaging, which is used to diagnose coronary artery disease.
owl:sameAs: n13:DB04853
dcterms:title: Binodenoson
adms:identifier: n6:11968305 n7:D03120 n8:9576912 n9:7851353 n10:DB04853
n3:mechanismOfAction: Binodenoson is a highly selective adenosine A2A receptor agonist. The adenosine A2A receptor is necessary for increased cardiac blood flow, and specificity to this particular receptor allows binodenoson to deliver, in a single injection, a more effective dose of medication with fewer side effects than current treatments, which typically require a 15-20 minute infusion. Cardiac stress tests allow physicians to identify the presence of cardiovascular disease by examining the flow of blood through the heart.
n3:synonym: 2-((Cyclohexylmethylene)hydrazino)adenosine MRE 0470
n3:IUPAC-Name: n4:271B59D8-363D-11E5-9242-09173F13E4C5
n3:InChI: n4:271B59DE-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula: n4:271B59DD-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight: n4:271B59DA-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight: n4:271B59DB-363D-11E5-9242-09173F13E4C5
n3:SMILES: n4:271B59DC-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility: n4:271B59D6-363D-11E5-9242-09173F13E4C5
n3:logP: n4:271B59D4-363D-11E5-9242-09173F13E4C5 n4:271B59D7-363D-11E5-9242-09173F13E4C5
n3:logS: n4:271B59D5-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count: n4:271B59E4-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count: n4:271B59E5-363D-11E5-9242-09173F13E4C5
n3:InChIKey: n4:271B59DF-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-: n4:271B59E0-363D-11E5-9242-09173F13E4C5
n3:Polarizability: n4:271B59E2-363D-11E5-9242-09173F13E4C5
n3:Refractivity: n4:271B59E1-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count: n4:271B59E3-363D-11E5-9242-09173F13E4C5
n3:casRegistryNumber: 144348-08-3
n3:category
n3:Bioavailability: n4:271B59EA-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter: n4:271B59EC-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule: n4:271B59ED-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings: n4:271B59E9-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge: n4:271B59E8-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five: n4:271B59EB-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name: n4:271B59D9-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-: n4:271B59E6-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-: n4:271B59E7-363D-11E5-9242-09173F13E4C5