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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n15http://linked.opendata.cz/resource/drugbank/drug/DB04833/identifier/chemspider/
n17http://bio2rdf.org/drugbank:
n6http://linked.opendata.cz/resource/drugbank/drug/DB04833/identifier/wikipedia/
admshttp://www.w3.org/ns/adms#
n14http://linked.opendata.cz/resource/drugbank/drug/DB04833/identifier/kegg-compound/
n13http://linked.opendata.cz/resource/drugbank/drug/DB04833/identifier/bindingdb/
n9http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
n12http://linked.opendata.cz/resource/drugbank/drug/DB04833/identifier/pubchem-compound/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n10http://linked.opendata.cz/resource/drugbank/drug/DB04833/identifier/pubchem-substance/
n4http://linked.opendata.cz/resource/drugbank/property/
n11http://linked.opendata.cz/resource/drugbank/drug/DB04833/identifier/kegg-drug/
n16http://linked.opendata.cz/resource/drugbank/drug/DB04833/identifier/drugbank/
xsdhhttp://www.w3.org/2001/XMLSchema#

Statements

Subject Item
n2:DB04833
rdf:type
n3:Drug
n3:description
Methaqualone is a sedative-hypnotic drug that is similar in effect to barbiturates, a general central nervous system depressant. The sedative-hypnotic activity was first noted by Indian researchers in the 1950s and in 1962 methaqualone itself was patented in the US by Wallace and Tiernan. Its use peaked in the early 1970s as a hypnotic, for the treatment of insomnia, and as a sedative and muscle relaxant. It has also been used illegally as a recreational drug, commonly known as Quaaludes, Sopors, Ludes or Mandrax (particularly in the 1970s in North America) depending on the manufacturer. Since at least 2001, it has been widely used in South Africa, where it is commonly referred to as "smarties" or "geluk-tablette" (meaning happy tablets). Clandestinely produced methaqualone is still seized by government agencies and police forces around the world. [Wikipedia]
n3:group
illicit withdrawn
n3:indication
For the treatment of insomnia, and as a sedative and muscle relaxant.
owl:sameAs
n9:DB04833 n17:DB04833
dcterms:title
Methaqualone
adms:identifier
n6:Methaqualone n10:46507178 n11:D00557 n12:6292 n13:50089081 n14:C07560 n15:6055 n16:DB04833
n3:toxicity
Symptoms of overdose include delirium, convulsions, muscle spasms or seizure, cardiac arrest, shortness or loss of breath, vomiting or nausea, and coma or death. The LD50 for mice is 1250 mg/kg and for rats is 326 mg/kg (Strasenburg Labs).
n3:synthesisReference
Potential Analgesics. Part I. Synthesis of substituted 4-quinazolones, I. K. Kacker and S. H. Zaheer, J. Ind. Chem. Soc. 28 (1951), pp. 344–346.
n3:IUPAC-Name
n4:271B57FA-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B5800-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B57FF-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B57FC-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B57FD-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B57FE-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B57F8-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B57F6-363D-11E5-9242-09173F13E4C5 n4:271B57F9-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B57F7-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n4:271B5806-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B5807-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B5801-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B5802-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B5804-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B5803-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B5805-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
72-44-6
n3:Bioavailability
n4:271B580B-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B580D-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B580E-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B580F-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B580A-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B5809-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B580C-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B57FB-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B5808-363D-11E5-9242-09173F13E4C5