This HTML5 document contains 77 embedded RDF statements represented using HTML+Microdata notation.

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Namespace Prefixes

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Statements

Subject Item
n2:DB04829
rdf:type
n4:Drug
n4:description
Debate continues over the nature and causes of chronic flashbacks. Explanations in terms of LSD physically remaining in the body for months or years after consumption have been discounted by experimental evidence. Some say HPPD is a manifestation of post-traumatic stress disorder, not related to the direct action of LSD on brain chemistry, and varies according to the susceptibility of the individual to the disorder. Many emotionally intense experiences can lead to flashbacks when a person is reminded acutely of the original experience. However, not all published case reports of chronic flashbacks appear to describe an anxious hyper-vigilant state reminiscent of post-traumatic stress disorder.
n4:generalReferences
# GREINER T, BURCH NR, EDELBERG R: Psychopathology and psychophysiology of minimal LSD-25 dosage; a preliminary dosage-response spectrum. AMA Arch Neurol Psychiatry. 1958 Feb;79(2):208-10. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/13497365 # AGHAJANIAN GK, BING OH: PERSISTENCE OF LYSERGIC ACID DIETHYLAMIDE IN THE PLASMA OF HUMAN SUBJECTS. Clin Pharmacol Ther. 1964 Sep-Oct;5:611-4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14209776 # Papac DI, Foltz RL: Measurement of lysergic acid diethylamide (LSD) in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry. J Anal Toxicol. 1990 May-Jun;14(3):189-90. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2374410 # Nichols DE: Hallucinogens. Pharmacol Ther. 2004 Feb;101(2):131-81. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14761703 # Jacobs BL, Heym J, Rasmussen K: Raphe neurons: firing rate correlates with size of drug response. Eur J Pharmacol. 1983 Jun 3;90(2-3):275-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/6873185 # AGHAJANIAN GK, BING OH: PERSISTENCE OF LYSERGIC ACID DIETHYLAMIDE IN THE PLASMA OF HUMAN SUBJECTS. Clin Pharmacol Ther. 1964 Sep-Oct;5:611-4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14209776
n4:group
withdrawn illicit
n4:halfLife
3 hours
owl:sameAs
n11:DB04829 n18:DB04829
dcterms:title
Lysergic Acid Diethylamide
adms:identifier
n7:5558 n8:DB04829 n9:21342 n12:Lysergic_acid_diethylamide n13:219 n14:C07542 n15:219 n16:5761 n17:46506397
n4:synonym
Lysergide LSD Lysergamid Lysergidum LSD-25 D-LSD Lysergaure diethylamid 9,10-Didehydro-N,N-diethyl-6-methylergoline-8b-carboxamide (+)-lysergic acid diethylamide Lysergamide D-lysergic acid dethylamide n,n-diethyl-(+)-lysergamide D-LSD-25 Lysergic acid amide N,n-diethyl-d-lysergamide N,N-Diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide D-lysergic acid diethylamide Lysergic acid diethylamide-25 N,n-diethyllysergamide Diethylamid kyseliny lysergove D-lysergic acid n,n-diethylamide (+)-LSD Dextrolysergic acid diethylamide
n4:toxicity
Estimates for the lethal dosage (LD50) of LSD range from 200 µg/kg to more than 1 mg/kg of human body mass, though most sources report that there are no known human cases of such an overdose.
n4:synthesisReference
Jean-Luc Henri Sigier Emmanuel, "Device for maintaining the inner surface of gun barrels and method for producing same." U.S. Patent US5657570, issued September, 1918.
n19:hasConcept
n20:M0012833
n4:IUPAC-Name
n5:271B578F-363D-11E5-9242-09173F13E4C5
n4:InChI
n5:271B5795-363D-11E5-9242-09173F13E4C5
n4:Molecular-Formula
n5:271B5794-363D-11E5-9242-09173F13E4C5
n4:Molecular-Weight
n5:271B5791-363D-11E5-9242-09173F13E4C5
n4:Monoisotopic-Weight
n5:271B5792-363D-11E5-9242-09173F13E4C5
n4:SMILES
n5:271B5793-363D-11E5-9242-09173F13E4C5
n4:Water-Solubility
n5:271B578D-363D-11E5-9242-09173F13E4C5
n4:logP
n5:271B578E-363D-11E5-9242-09173F13E4C5 n5:271B578B-363D-11E5-9242-09173F13E4C5 n5:271B57A6-363D-11E5-9242-09173F13E4C5
n4:logS
n5:271B578C-363D-11E5-9242-09173F13E4C5
n4:pKa
n5:271B57A7-363D-11E5-9242-09173F13E4C5
n4:H-Bond-Acceptor-Count
n5:271B579B-363D-11E5-9242-09173F13E4C5
n4:H-Bond-Donor-Count
n5:271B579C-363D-11E5-9242-09173F13E4C5
n4:InChIKey
n5:271B5796-363D-11E5-9242-09173F13E4C5
n4:Polar-Surface-Area--PSA-
n5:271B5797-363D-11E5-9242-09173F13E4C5
n4:Polarizability
n5:271B5799-363D-11E5-9242-09173F13E4C5
n4:Refractivity
n5:271B5798-363D-11E5-9242-09173F13E4C5
n4:Rotatable-Bond-Count
n5:271B579A-363D-11E5-9242-09173F13E4C5
n4:absorption
Rapidly absorbed.
n4:affectedOrganism
Humans and other mammals
n4:casRegistryNumber
50-37-3
n4:category
n4:Bioavailability
n5:271B57A1-363D-11E5-9242-09173F13E4C5
n4:Ghose-Filter
n5:271B57A3-363D-11E5-9242-09173F13E4C5
n4:MDDR-Like-Rule
n5:271B57A4-363D-11E5-9242-09173F13E4C5
n4:Melting-Point
n5:271B57A5-363D-11E5-9242-09173F13E4C5
n4:Number-of-Rings
n5:271B57A0-363D-11E5-9242-09173F13E4C5
n4:Physiological-Charge
n5:271B579F-363D-11E5-9242-09173F13E4C5
n4:Rule-of-Five
n5:271B57A2-363D-11E5-9242-09173F13E4C5
n4:Traditional-IUPAC-Name
n5:271B5790-363D-11E5-9242-09173F13E4C5
n4:pKa--strongest-acidic-
n5:271B579D-363D-11E5-9242-09173F13E4C5
n4:pKa--strongest-basic-
n5:271B579E-363D-11E5-9242-09173F13E4C5