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Namespace Prefixes

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Statements

Subject Item
n2:DB04788
rdf:type
n3:Drug
n3:description
Tagetitoxin is a bacterial phytotoxin. It preferentially inhibits eukaryotic RNA polymerase.
n3:generalReferences
# Plet JR, Porter MJ: Synthesis of the bicyclic core of tagetitoxin. Chem Commun (Camb). 2006 Mar 21;(11):1197-9. Epub 2006 Feb 14. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16518489 # Vassylyev DG, Svetlov V, Vassylyeva MN, Perederina A, Igarashi N, Matsugaki N, Wakatsuki S, Artsimovitch I: Structural basis for transcription inhibition by tagetitoxin. Nat Struct Mol Biol. 2005 Dec;12(12):1086-93. Epub 2005 Nov 6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16273103 # Mathews DE, Durbin RD: Mechanistic aspects of tagetitoxin inhibition of RNA polymerase from Escherichia coli. Biochemistry. 1994 Oct 4;33(39):11987-92. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7918417 # Steinberg TH, Mathews DE, Durbin RD, Burgess RR: Tagetitoxin: a new inhibitor of eukaryotic transcription by RNA polymerase III. J Biol Chem. 1990 Jan 5;265(1):499-505. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2403565
n3:group
experimental
owl:sameAs
n6:DB04788 n9:DB04788
dcterms:title
Tagetitoxin
adms:identifier
n12:TGT n13:5327077 n14:DB04788 n15:46506068
n3:mechanismOfAction
Tagetitoxin inhibits all RNAP catalytic reactions. Tagetitoxin binding is mediated exclusively through polar interactions with the beta and beta' residues whose substitutions confer resistance to tagetitoxin in vitro.
n3:synonym
(1R,4R,5R,6R,7S,8R)-6-ACETOXY-7-AMINO-4-CARBAMOYL-4-HYDROXY-8-(PHOSPHONOOXY)-9-OXA-3-THIABICYCLO[3.3.1]NONANE-1-CARBOXYLIC ACID
n7:hasConcept
n8:M0172306
n3:IUPAC-Name
n4:271B5385-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B538B-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B538A-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B5387-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B5388-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B5389-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B5383-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B5381-363D-11E5-9242-09173F13E4C5 n4:271B5384-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B5382-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n4:271B5391-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B5392-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B538C-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B538D-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B538F-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B538E-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B5390-363D-11E5-9242-09173F13E4C5
n3:casRegistryNumber
87913-21-1
n3:Bioavailability
n4:271B5397-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B5399-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B539A-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B5396-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B5395-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B5398-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B5386-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B5393-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B5394-363D-11E5-9242-09173F13E4C5