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Namespace Prefixes

PrefixIRI
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n15http://linked.opendata.cz/resource/drugbank/drug/DB04575/identifier/chemspider/
dctermshttp://purl.org/dc/terms/
n14http://linked.opendata.cz/resource/drugbank/drug/DB04575/identifier/chebi/
n20http://linked.opendata.cz/resource/mesh/concept/
n17http://linked.opendata.cz/resource/drugbank/drug/DB04575/identifier/wikipedia/
n16http://linked.opendata.cz/resource/drugbank/drug/DB04575/identifier/pharmgkb/
n18http://bio2rdf.org/drugbank:
n13http://linked.opendata.cz/resource/drugbank/drug/DB04575/identifier/kegg-compound/
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n19http://linked.opendata.cz/ontology/mesh/
owlhttp://www.w3.org/2002/07/owl#
n6http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#

Statements

Subject Item
n2:DB04575
rdf:type
n5:Drug
n5:description
The 3-cyclopentyl ether of ethinyl estradiol.
n5:group
approved
n5:indication
Used in hormone replacement therapy, treating symptoms of menopause such as hot flashes. Also used to treat breast and prostate cancer.
owl:sameAs
n4:DB04575 n18:DB04575
dcterms:title
Quinestrol
adms:identifier
n9:9046 n10:46508939 n11:D00576 n12:DB04575 n13:C07619 n14:8716 n15:8694 n16:PA164749042 n17:Quinestrol
n5:mechanismOfAction
Estrogens diffuse into their target cells and interact with a protein receptor (the estrogen receptor). Estrogen interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).
n5:synonym
Quilea Estradiol-17-beta 3-cyclopentyl ether 17alpha-Ethynylestradiol 3-cyclopentyl ether Estrovis Eston Estrovister Plestrovis Estrovis 4000 Quinestrol ethinyl estradiol 3-cyclopentyl ether Quinestrolum Quinestrolo 17-alpha-Ethinylestradiol 3-cyclopentyl ether
n5:toxicity
Symptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females.
n19:hasConcept
n20:M0018337
n5:IUPAC-Name
n6:271B3FDE-363D-11E5-9242-09173F13E4C5
n5:InChI
n6:271B3FE4-363D-11E5-9242-09173F13E4C5
n5:Molecular-Formula
n6:271B3FE3-363D-11E5-9242-09173F13E4C5
n5:Molecular-Weight
n6:271B3FE0-363D-11E5-9242-09173F13E4C5
n5:Monoisotopic-Weight
n6:271B3FE1-363D-11E5-9242-09173F13E4C5
n5:SMILES
n6:271B3FE2-363D-11E5-9242-09173F13E4C5
n5:Water-Solubility
n6:271B3FDC-363D-11E5-9242-09173F13E4C5
n5:logP
n6:271B3FDA-363D-11E5-9242-09173F13E4C5 n6:271B3FDD-363D-11E5-9242-09173F13E4C5
n5:logS
n6:271B3FDB-363D-11E5-9242-09173F13E4C5
n5:H-Bond-Acceptor-Count
n6:271B3FEA-363D-11E5-9242-09173F13E4C5
n5:H-Bond-Donor-Count
n6:271B3FEB-363D-11E5-9242-09173F13E4C5
n5:InChIKey
n6:271B3FE5-363D-11E5-9242-09173F13E4C5
n5:Polar-Surface-Area--PSA-
n6:271B3FE6-363D-11E5-9242-09173F13E4C5
n5:Polarizability
n6:271B3FE8-363D-11E5-9242-09173F13E4C5
n5:Refractivity
n6:271B3FE7-363D-11E5-9242-09173F13E4C5
n5:Rotatable-Bond-Count
n6:271B3FE9-363D-11E5-9242-09173F13E4C5
n5:absorption
Absorbed following oral administration.
n5:affectedOrganism
Humans and other mammals
n5:casRegistryNumber
152-43-2
n5:category
n5:Bioavailability
n6:271B3FF0-363D-11E5-9242-09173F13E4C5
n5:Ghose-Filter
n6:271B3FF2-363D-11E5-9242-09173F13E4C5
n5:MDDR-Like-Rule
n6:271B3FF3-363D-11E5-9242-09173F13E4C5
n5:Melting-Point
n6:271B3FF4-363D-11E5-9242-09173F13E4C5
n5:Number-of-Rings
n6:271B3FEF-363D-11E5-9242-09173F13E4C5
n5:Physiological-Charge
n6:271B3FEE-363D-11E5-9242-09173F13E4C5
n5:Rule-of-Five
n6:271B3FF1-363D-11E5-9242-09173F13E4C5
n5:Traditional-IUPAC-Name
n6:271B3FDF-363D-11E5-9242-09173F13E4C5
n5:pKa--strongest-acidic-
n6:271B3FEC-363D-11E5-9242-09173F13E4C5
n5:pKa--strongest-basic-
n6:271B3FED-363D-11E5-9242-09173F13E4C5