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Namespace Prefixes

PrefixIRI
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Statements

Subject Item
n2:DB01783
rdf:type
n3:Drug
n3:description
Pantothenic acid, also called pantothenate or vitamin B5 (a B vitamin), is a water-soluble vitamin discovered by Roger J. Williams in 1919. For many animals, pantothenic acid is an essential nutrient. Animals require pantothenic acid to synthesize coenzyme-A (CoA), as well as to synthesize and metabolize proteins, carbohydrates, and fats. Pantothenic acid is the amide between pantoic acid and β-alanine. Small quantities of pantothenic acid are found in nearly every food, with high amounts in whole-grain cereals, legumes, eggs, meat, royal jelly, avocado, and yogurt. It is commonly found as its alcohol analog, the provitamin panthenol, and as calcium pantothenate. Pantothenic acid is an ingredient in some hair and skin care products. Only the dextrorotatory (D) isomer of pantothenic acid possesses biologic activity. The levorotatory (L) form may antagonize the effects of the dextrorotatory isomer. [Wikipedia]
n3:generalReferences
# Trumbo, P. R. (2006). "Pantothenic Acid". In Shils, M. E.; Shike, M.; Ross, A. C. et al.. Modern Nutrition in Health and Disease (10th ed.). Philadelphia, PA: Lippincott Williams & Wilkins. pp. 462–467. ISBN 0-7817-4133-5.
n3:group
nutraceutical
n3:indication
Studied for the treatment of many uses such as treatment of testicular torsion, diabetic ulceration, wound healing, acne, obesity, diabetic peripheral polyneuropathy. It has also been investigated for its hypolipidemic effects and as cholesterol lowering agent.
owl:sameAs
n6:DB01783 n12:DB01783
dcterms:title
Pantothenic acid
adms:identifier
n8:D07413 n9:Pantothenic_acid n10:7916 n11:C00864 n13:PAU n14:DB01783
n3:mechanismOfAction
Pantothenic acid is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE.
n3:synonym
Pantothenate (+)-Pantothenic acid Vitamin B5 D-pantothenic acid
n3:toxicity
No Tolerable Upper Level Intake (UL) has been established for the vitamin.
n3:salt
n3:synthesisReference
John F. Verbeeck, "Process for the production of the calcium salt of pantothenic acid." U.S. Patent US3935256, issued February, 1971.
n3:IUPAC-Name
n4:271B4635-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B463B-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B463A-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B4637-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B4638-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B4639-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B464B-363D-11E5-9242-09173F13E4C5 n4:271B4633-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B4634-363D-11E5-9242-09173F13E4C5 n4:271B4631-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B4632-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n4:271B4641-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B4642-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B463C-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B463D-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B463F-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B463E-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B4640-363D-11E5-9242-09173F13E4C5
n3:absorption
When found in foods, most pantothenic acid is in the form of CoA or acyl carrier protein (ACP). For the intestinal cells to absorb this vitamin, it must be converted into free pantothenic acid. Within the lumen of the intestine, CoA and ACP are hydrolyzed into 4'-phosphopantetheine. The 4'-phosphopantetheine is then dephosphorylated into pantetheine. Pantetheinase, an intestinal enzyme, then hydrolyzes pantetheine into free pantothenic acid. Free pantothenic acid is absorbed into intestinal cells via a saturable, sodium-dependent active transport system. At high levels of intake, when this mechanism is saturated, some pantothenic acid may also be absorbed via passive diffusion. As intake increases 10-fold, however, absorption rate decreases to 10%. [Wikipedia]
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
79-83-4
n3:category
n3:Bioavailability
n4:271B4647-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B4649-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B464A-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B464C-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B4646-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B4645-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B4648-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B4636-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B4643-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B4644-363D-11E5-9242-09173F13E4C5