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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n15http://linked.opendata.cz/resource/drugbank/drug/DB01603/identifier/chemspider/
n21http://linked.opendata.cz/resource/mesh/concept/
n14http://linked.opendata.cz/resource/drugbank/drug/DB01603/identifier/chebi/
n16http://linked.opendata.cz/resource/drugbank/drug/DB01603/identifier/wikipedia/
n17http://linked.opendata.cz/resource/drugbank/drug/DB01603/identifier/pharmgkb/
n5http://bio2rdf.org/drugbank:
n13http://linked.opendata.cz/resource/drugbank/drug/DB01603/identifier/kegg-compound/
admshttp://www.w3.org/ns/adms#
n11http://linked.opendata.cz/resource/drugbank/drug/DB01603/identifier/pubchem-compound/
n18http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
n9http://linked.opendata.cz/resource/drugbank/drug/DB01603/identifier/pubchem-substance/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
owlhttp://www.w3.org/2002/07/owl#
n12http://linked.opendata.cz/resource/drugbank/drug/DB01603/identifier/drugbank/
n20http://linked.opendata.cz/ontology/mesh/
n3http://linked.opendata.cz/ontology/drugbank/
n10http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n7http://linked.opendata.cz/resource/atc/
n6http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB01603
rdf:type
n3:Drug
n3:description
One of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection. [PubChem]
n3:group
approved
n3:halfLife
25-60 minutes
n3:indication
Used to treat infections caused by susceptible Gram-positive bacteria, particularly beta-lactamase-producing organisms such as <i>Staphylococcus aureus</i> that would otherwise be resistant to most penicillins.
owl:sameAs
n5:DB01603 n18:DB01603
dcterms:title
Meticillin
adms:identifier
n9:46508973 n11:6087 n12:DB01603 n13:C07177 n14:6827 n15:5862 n16:Methicillin n17:PA164777034
n3:mechanismOfAction
Like other beta-lactam antibiotics, meticillin acts by inhibiting the synthesis of bacterial cell walls. It inhibits cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell wall of Gram-positive bacteria. It does this by binding to and competitively inhibiting the transpeptidase enzyme used by bacteria to cross-link the peptide (D-alanyl-alanine) used in peptidogylcan synthesis.
n3:synonym
Meticilline Methicillin Meticillinum Meticillin 6beta-(2,6-Dimethoxybenzamido)penicillanic acid Methycillin (2,6-Dimethoxyphenyl)penicillin 6-(2,6-Dimethoxybenzamido)penicillanic acid Meticilina Methicillinum (2S,5R,6R)-6-[(2,6-Dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
n20:hasConcept
n21:M0013570
n3:IUPAC-Name
n10:271B5AEB-363D-11E5-9242-09173F13E4C5
n3:InChI
n10:271B5AF1-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n10:271B5AF0-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n10:271B5AED-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n10:271B5AEE-363D-11E5-9242-09173F13E4C5
n3:SMILES
n10:271B5AEF-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n10:271B5AE9-363D-11E5-9242-09173F13E4C5
n3:logP
n10:271B5AE7-363D-11E5-9242-09173F13E4C5 n10:271B5AEA-363D-11E5-9242-09173F13E4C5 n10:271B5B01-363D-11E5-9242-09173F13E4C5
n3:logS
n10:271B5AE8-363D-11E5-9242-09173F13E4C5
n3:pKa
n10:271B5B02-363D-11E5-9242-09173F13E4C5
n6:hasATCCode
n7:J01CF03
n3:H-Bond-Acceptor-Count
n10:271B5AF7-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n10:271B5AF8-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n10:271B5AF2-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n10:271B5AF3-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n10:271B5AF5-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n10:271B5AF4-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n10:271B5AF6-363D-11E5-9242-09173F13E4C5
n3:absorption
Not absorbed following oral administration.
n3:affectedOrganism
Streptococcus pneumoniae Staphylococcus aureus Streptococcus pyogenes Gram-positive Bacteria Enteric bacteria and other eubacteria Staphylococcus epidermidis
n3:casRegistryNumber
61-32-5
n3:category
n3:Bioavailability
n10:271B5AFD-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n10:271B5AFF-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n10:271B5B00-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n10:271B5AFC-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n10:271B5AFB-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n10:271B5AFE-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n10:271B5AEC-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n10:271B5AF9-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n10:271B5AFA-363D-11E5-9242-09173F13E4C5