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Namespace Prefixes

PrefixIRI
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n2http://linked.opendata.cz/resource/drugbank/drug/
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n5http://linked.opendata.cz/resource/drugbank/drug/DB01592/identifier/chemspider/
n7http://linked.opendata.cz/resource/drugbank/drug/DB01592/identifier/chebi/
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n25http://linked.opendata.cz/resource/drugbank/drug/DB01592/identifier/wikipedia/
n13http://linked.opendata.cz/resource/drugbank/drug/DB01592/identifier/pharmgkb/
n17http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/
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n10http://linked.opendata.cz/resource/drugbank/drug/DB01592/identifier/kegg-compound/
n8http://linked.opendata.cz/resource/drugbank/drug/DB01592/identifier/pubchem-compound/
xsdhhttp://www.w3.org/2001/XMLSchema#
n11http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB01592
rdf:type
n3:Drug
n3:description
A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletion of iron stores may result in iron-deficiency anemia. Iron is used to build up the blood in anemia.
n3:dosage
n21:271B596D-363D-11E5-9242-09173F13E4C5 n21:271B596E-363D-11E5-9242-09173F13E4C5 n21:271B596F-363D-11E5-9242-09173F13E4C5 n21:271B5970-363D-11E5-9242-09173F13E4C5 n21:271B5971-363D-11E5-9242-09173F13E4C5
n3:group
approved
n3:indication
Used in preventing and treating iron-deficiency anemia.
owl:sameAs
n19:DB01592 n22:DB01592
dcterms:title
Iron
adms:identifier
n5:22368 n6:DB01592 n7:18248 n8:23925 n9:46509190 n10:C00023 n13:PA450087 n25:Iron n26:59338-775
n3:mechanismOfAction
Iron is necessary for the production of hemoglobin. Iron-deficiency can lead to decreased production of hemoglobin and a microcytic, hypochromic anemia.
n3:packager
n14:271B5960-363D-11E5-9242-09173F13E4C5 n14:271B5961-363D-11E5-9242-09173F13E4C5 n14:271B595E-363D-11E5-9242-09173F13E4C5 n14:271B595F-363D-11E5-9242-09173F13E4C5 n14:271B595C-363D-11E5-9242-09173F13E4C5 n14:271B5969-363D-11E5-9242-09173F13E4C5 n14:271B595D-363D-11E5-9242-09173F13E4C5 n14:271B596A-363D-11E5-9242-09173F13E4C5 n14:271B595A-363D-11E5-9242-09173F13E4C5 n14:271B5967-363D-11E5-9242-09173F13E4C5 n14:271B595B-363D-11E5-9242-09173F13E4C5 n14:271B5968-363D-11E5-9242-09173F13E4C5 n14:271B5958-363D-11E5-9242-09173F13E4C5 n14:271B5955-363D-11E5-9242-09173F13E4C5 n14:271B5959-363D-11E5-9242-09173F13E4C5 n14:271B5956-363D-11E5-9242-09173F13E4C5 n14:271B5957-363D-11E5-9242-09173F13E4C5 n14:271B5966-363D-11E5-9242-09173F13E4C5 n14:271B5964-363D-11E5-9242-09173F13E4C5 n14:271B5965-363D-11E5-9242-09173F13E4C5 n14:271B5962-363D-11E5-9242-09173F13E4C5 n14:271B5963-363D-11E5-9242-09173F13E4C5
n3:synonym
Hierro fer Iron 26Fe Ferrum Eisen Fe
n3:toxicity
Acute iron overdosage can be divided into four stages. In the first stage, which occurs up to six hours after ingestion, the principal symptoms are vomiting and diarrhea. Other symptoms include hypotension, tachycardia and CNS depression ranging from lethargy to coma. The second phase may occur at 6-24 hours after ingestion and is characterized by a temporary remission. In the third phase, gastrointestinal symptoms recur accompanied by shock, metabolic acidosis, coma, hepatic necrosis and jaundice, hypoglycemia, renal failure and pulmonary edema. The fourth phase may occur several weeks after ingestion and is characterized by gastrointestinal obstruction and liver damage. In a young child, 75 milligrams per kilogram is considered extremely dangerous. A dose of 30 milligrams per kilogram can lead to symptoms of toxicity. Estimates of a lethal dosage range from 180 milligrams per kilogram and upwards. A peak serum iron concentration of five micrograms or more per ml is associated with moderate to severe poisoning in many.
n11:hasAHFSCode
n12:20-04-00 n12:20-04-04 n12:92-02-00%2A n12:88-29-00%2A
n3:mixture
n23:271B5954-363D-11E5-9242-09173F13E4C5 n23:271B5953-363D-11E5-9242-09173F13E4C5
n3:salt
n3:synthesisReference
Walter Lugscheider, Paul Mullner, Wilhelm Schiffer, Alois Leutgob, "Arrangement for producing metals, such as molten pig iron, steel pre-material and ferroalloys." U.S. Patent US4617671, issued 0000.
foaf:page
n17:iro_0149.shtml n24:ferrous-gluconate.html n28:fedex.htm
n3:IUPAC-Name
n15:271B5973-363D-11E5-9242-09173F13E4C5
n3:InChI
n15:271B5979-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n15:271B5978-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n15:271B5975-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n15:271B5976-363D-11E5-9242-09173F13E4C5
n3:SMILES
n15:271B5977-363D-11E5-9242-09173F13E4C5
n3:logP
n15:271B5972-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n15:271B597F-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n15:271B5980-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n15:271B597A-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n15:271B597B-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n15:271B597D-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n15:271B597C-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n15:271B597E-363D-11E5-9242-09173F13E4C5
n3:absorption
The efficiency of absorption depends on the salt form, the amount administered, the dosing regimen and the size of iron stores. Subjects with normal iron stores absorb 10% to 35% of an iron dose. Those who are iron deficient may absorb up to 95% of an iron dose.
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
7439-89-6
n3:category
n3:containedIn
n20:271B596B-363D-11E5-9242-09173F13E4C5 n20:271B596C-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n15:271B5983-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n15:271B5985-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n15:271B5986-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n15:271B5987-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n15:271B5982-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n15:271B5981-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n15:271B5984-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n15:271B5974-363D-11E5-9242-09173F13E4C5