This HTML5 document contains 69 embedded RDF statements represented using HTML+Microdata notation.

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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n19http://linked.opendata.cz/resource/mesh/concept/
foafhttp://xmlns.com/foaf/0.1/
n10http://linked.opendata.cz/resource/drugbank/drug/DB01452/identifier/chemspider/
n8http://www.drugs.com/
n12http://linked.opendata.cz/resource/drugbank/drug/DB01452/identifier/chebi/
n15http://bio2rdf.org/drugbank:
n20http://linked.opendata.cz/resource/drugbank/drug/DB01452/identifier/wikipedia/
admshttp://www.w3.org/ns/adms#
n17http://linked.opendata.cz/resource/drugbank/drug/DB01452/identifier/pharmgkb/
n16http://linked.opendata.cz/resource/drugbank/drug/DB01452/identifier/kegg-compound/
n6http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n13http://linked.opendata.cz/resource/drugbank/drug/DB01452/identifier/pubchem-compound/
owlhttp://www.w3.org/2002/07/owl#
n18http://linked.opendata.cz/ontology/mesh/
n3http://linked.opendata.cz/ontology/drugbank/
n14http://linked.opendata.cz/resource/drugbank/drug/DB01452/identifier/pubchem-substance/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n11http://linked.opendata.cz/resource/drugbank/drug/DB01452/identifier/drugbank/
n22http://linked.opendata.cz/resource/atc/
n21http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB01452
rdf:type
n3:Drug
n3:description
A narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) Internationally, heroin is controlled under Schedules I and IV of the Single Convention on Narcotic Drugs. It is illegal to manufacture, possess, or sell heroin in the United States and the UK. However, under the name diamorphine, heroin is a legal prescription drug in the United Kingdom.
n3:generalReferences
# Tschacher W, Haemmig R, Jacobshagen N: Time series modeling of heroin and morphine drug action. Psychopharmacology (Berl). 2003 Jan;165(2):188-93. Epub 2002 Oct 29. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12404073
n3:group
illicit approved
n3:halfLife
<10 minutes
n3:indication
Used in the treatment of acute pain, myocardial infarction, acute pulmonary oedema, and chronic pain.
owl:sameAs
n6:DB01452 n15:DB01452
dcterms:title
Heroin
adms:identifier
n10:4575379 n11:DB01452 n12:27808 n13:5462328 n14:46506839 n16:C06534 n17:PA452619 n20:Heroin
n3:mechanismOfAction
Heroin is a mu-opioid agonist. It acts on endogenous mu-opioid receptors that are spread in discrete packets throughout the brain, spinal cord and gut in almost all mammals. Heroin, along with other opioids, are agonists to four endogenous neurotransmitters. They are beta-endorphin, dynorphin, leu-enkephalin, and met-enkephalin. The body responds to heroin in the brain by reducing (and sometimes stopping) production of the endogenous opioids when heroin is present. Endorphins are regularly released in the brain and nerves, attenuating pain. Their other functions are still obscure, but are probably related to the effects produced by heroin besides analgesia (antitussin, anti-diarrheal).
n3:routeOfElimination
90% renal as glucuronides, rest biliary
n3:synonym
Heroin diacetylmorphine O,O'-diacetylmorphine (5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol diacetate (ester) morphine diacetate diamorphine 7,8-Dihydro-4,5-alpha-epoxy-17-methylmorphinan-3,6-alpha-diol diacetate 3,6-Diacetylmorphine
n3:foodInteraction
Avoid alcohol To avoid constipation: increase your daily intake of fiber (beans, whole grains, vegetables).
n3:proteinBinding
0% (morphine metabolite 35%)
n3:salt
n18:hasConcept
n19:M0006166
foaf:page
n8:heroin.html
n3:IUPAC-Name
n4:271B4C44-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B4C4A-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B4C49-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B4C46-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B4C47-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B4C48-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B4C42-363D-11E5-9242-09173F13E4C5 n4:271B4C59-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B4C43-363D-11E5-9242-09173F13E4C5 n4:271B4C40-363D-11E5-9242-09173F13E4C5 n4:271B4C5C-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B4C41-363D-11E5-9242-09173F13E4C5
n3:pKa
n4:271B4C5D-363D-11E5-9242-09173F13E4C5
n21:hasATCCode
n22:N07BC06
n3:H-Bond-Acceptor-Count
n4:271B4C50-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B4C51-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B4C4B-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B4C4C-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B4C4E-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B4C4D-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B4C4F-363D-11E5-9242-09173F13E4C5
n3:absorption
Bioavailability is less than 35%.
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
561-27-3
n3:category
n3:Bioavailability
n4:271B4C55-363D-11E5-9242-09173F13E4C5
n3:Boiling-Point
n4:271B4C5B-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B4C57-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B4C58-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B4C5A-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B4C54-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B4C53-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B4C56-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B4C45-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B4C52-363D-11E5-9242-09173F13E4C5