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Namespace Prefixes

PrefixIRI
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n16http://linked.opendata.cz/resource/drugbank/drug/DB01414/identifier/kegg-drug/
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n14http://linked.opendata.cz/resource/drugbank/drug/DB01414/identifier/wikipedia/
n13http://linked.opendata.cz/resource/drugbank/drug/DB01414/identifier/pharmgkb/
n8http://linked.opendata.cz/resource/atc/
n7http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB01414
rdf:type
n3:Drug
n3:description
A derivative of 7-aminocephalosporanic acid.
n3:group
approved
n3:halfLife
1.2 hours
n3:indication
Cefacetrile is a broad-spectrum first generation cephalosporin antibiotic effective in Gram-positive and Gram-negative bacterial infections.
owl:sameAs
n6:DB01414 n9:DB01414
dcterms:title
Cefacetrile
adms:identifier
n13:PA164776752 n14:Cefacetrile n15:46504767 n16:D07629 n17:91562 n18:82675 n19:DB01414
n3:mechanismOfAction
In vitro tests demonstrate that the bactericidal action of cephalosporins results from inhibition of cell wall synthesis. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.
n3:synonym
Cefacetrilo Cephacetrile Cefacetrilum Vetrimast [veterinary]
n3:volumeOfDistribution
Vd of 0.2 to 0.5L/.kg
n3:proteinBinding
23 to 38%
n3:synthesisReference
Bickel, H., Bosshardt, R., Fechtig, B., Schenker, K. and Urech, J.; U.S. Patent 3,483,197; December 9,1969; assigned to Ciba Corporation.
n10:hasConcept
n11:M0003817
n3:IUPAC-Name
n4:271B4809-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B480F-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B480E-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B480B-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B480C-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B480D-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B4807-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B4820-363D-11E5-9242-09173F13E4C5 n4:271B4805-363D-11E5-9242-09173F13E4C5 n4:271B4808-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B4806-363D-11E5-9242-09173F13E4C5
n7:hasATCCode
n8:J01DB10
n3:H-Bond-Acceptor-Count
n4:271B4815-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B4816-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B4810-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B4811-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B4813-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B4812-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B4814-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Enteric bacteria and other eubacteria
n3:casRegistryNumber
10206-21-0
n3:category
n3:Bioavailability
n4:271B481B-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B481D-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B481E-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B481F-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B481A-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B4819-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B481C-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B480A-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B4817-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B4818-363D-11E5-9242-09173F13E4C5