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Namespace Prefixes

PrefixIRI
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n18http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB01408
rdf:type
n5:Drug
n5:description
Bambuterol is a long acting beta-adrenoceptor agonist used in the treatment of asthma. It is a prodrug of terbutaline.
n5:group
approved
n5:halfLife
13 hours for bambuterol and 21 hours for the primary active metabolite terbutaline.
n5:indication
For the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema.
owl:sameAs
n8:DB01408 n17:DB01408
dcterms:title
Bambuterol
adms:identifier
n4:PA164743113 n9:553827 n11:54766 n14:46505785 n15:49466 n16:DB01408 n20:Bambuterol
n5:mechanismOfAction
The pharmacologic effects of bambuterol are at least in part attributable to stimulation through beta-adrenergic receptors (beta 2 receptors) of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic AMP. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
n5:synonym
Terbutaline bisdimethylcarbamate Bambuterol Terbutaline bis(dimethylcarbamate) (+-)-5-(2-(Tert-butylamino)-1-hydroxyethyl)-m-phenylene bis(dimethylcarbamate) Bambuterolum
n5:salt
n5:synthesisReference
Peter Jaksch, "Method of preparing an intermediate for the manufacture of bambuterol." U.S. Patent US5200551, issued May, 1986.
n12:hasConcept
n13:M0137788
n5:IUPAC-Name
n6:271B4730-363D-11E5-9242-09173F13E4C5
n5:InChI
n6:271B4736-363D-11E5-9242-09173F13E4C5
n5:Molecular-Formula
n6:271B4735-363D-11E5-9242-09173F13E4C5
n5:Molecular-Weight
n6:271B4732-363D-11E5-9242-09173F13E4C5
n5:Monoisotopic-Weight
n6:271B4733-363D-11E5-9242-09173F13E4C5
n5:SMILES
n6:271B4734-363D-11E5-9242-09173F13E4C5
n5:Water-Solubility
n6:271B472E-363D-11E5-9242-09173F13E4C5
n5:logP
n6:271B472F-363D-11E5-9242-09173F13E4C5 n6:271B472C-363D-11E5-9242-09173F13E4C5
n5:logS
n6:271B472D-363D-11E5-9242-09173F13E4C5
n18:hasATCCode
n19:R03CC12
n5:H-Bond-Acceptor-Count
n6:271B473C-363D-11E5-9242-09173F13E4C5
n5:H-Bond-Donor-Count
n6:271B473D-363D-11E5-9242-09173F13E4C5
n5:InChIKey
n6:271B4737-363D-11E5-9242-09173F13E4C5
n5:Polar-Surface-Area--PSA-
n6:271B4738-363D-11E5-9242-09173F13E4C5
n5:Polarizability
n6:271B473A-363D-11E5-9242-09173F13E4C5
n5:Refractivity
n6:271B4739-363D-11E5-9242-09173F13E4C5
n5:Rotatable-Bond-Count
n6:271B473B-363D-11E5-9242-09173F13E4C5
n5:absorption
Bioavailability is 20% following oral administration.
n5:affectedOrganism
Humans and other mammals
n5:casRegistryNumber
81732-46-9
n5:Bioavailability
n6:271B4742-363D-11E5-9242-09173F13E4C5
n5:Ghose-Filter
n6:271B4744-363D-11E5-9242-09173F13E4C5
n5:MDDR-Like-Rule
n6:271B4745-363D-11E5-9242-09173F13E4C5
n5:Number-of-Rings
n6:271B4741-363D-11E5-9242-09173F13E4C5
n5:Physiological-Charge
n6:271B4740-363D-11E5-9242-09173F13E4C5
n5:Rule-of-Five
n6:271B4743-363D-11E5-9242-09173F13E4C5
n5:Traditional-IUPAC-Name
n6:271B4731-363D-11E5-9242-09173F13E4C5
n5:pKa--strongest-acidic-
n6:271B473E-363D-11E5-9242-09173F13E4C5
n5:pKa--strongest-basic-
n6:271B473F-363D-11E5-9242-09173F13E4C5