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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n10http://linked.opendata.cz/resource/drugbank/drug/DB01401/identifier/drugbank/
n6http://linked.opendata.cz/resource/drugbank/company/
n11http://bio2rdf.org/drugbank:
admshttp://www.w3.org/ns/adms#
n8http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n5http://linked.opendata.cz/resource/drugbank/medicinal-product/
owlhttp://www.w3.org/2002/07/owl#
n12http://linked.opendata.cz/resource/drugbank/drug/DB01401/identifier/pharmgkb/
n3http://linked.opendata.cz/ontology/drugbank/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#

Statements

Subject Item
n2:DB01401
rdf:type
n3:Drug
n3:description
Choline magnesium trisalicylate is a non-acetylated salicylate used widely as a nonsteroidal anti-inflammatory drug. Trisalicylate significantly reduces methotrexate renal clearance, displacing methotrexate from protein, increasing the fraction unbound by 28%.(PMID: 1728115, 1618240)
n3:group
approved
n3:indication
Choline magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults.
owl:sameAs
n8:DB01401 n11:DB01401
dcterms:title
Trisalicylate-choline
adms:identifier
n10:DB01401 n12:PA164749164
n3:mechanismOfAction
Inhibits prostaglandin synthesis; acts on the hypothalamus heat-regulating center to reduce fever; blocks the generation of pain impulses
n3:packager
n6:271B466B-363D-11E5-9242-09173F13E4C5 n6:271B466C-363D-11E5-9242-09173F13E4C5
n3:routeOfElimination
renal
n3:synonym
Tricosal
n3:toxicity
Salicylate intoxication, known as salicylism, may occur with large doses or extended therapy. Common symptoms of salicylism include headache, dizziness, tinnitus, hearing impairment, confusion, drowsiness, sweating, vomiting, diarrhea, and hyperventilation. A more severe degree of salicylate intoxication can lead to CNS disturbances, alteration in electrolyte balance, respiratory and metabolic acidosis, hyperthermia, and dehydration.
n3:IUPAC-Name
n4:271B4671-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B4677-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B4676-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B4673-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B4674-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B4675-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B4670-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n4:271B467D-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B467E-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B4678-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B4679-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B467B-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B467A-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B467C-363D-11E5-9242-09173F13E4C5
n3:containedIn
n5:271B466D-363D-11E5-9242-09173F13E4C5 n5:271B466E-363D-11E5-9242-09173F13E4C5 n5:271B466F-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n4:271B4683-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B4685-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B4686-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B4682-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B4681-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B4684-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B4672-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B467F-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B4680-363D-11E5-9242-09173F13E4C5