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Namespace Prefixes

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Statements

Subject Item
n2:DB01373
rdf:type
n3:Drug
n3:description
Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast.
n3:generalReferences
# Dawson-Hughes B, Harris SS, Krall EA, Dallal GE: Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med. 1997 Sep 4;337(10):670-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9278463 # Weingarten MA, Zalmanovici A, Yaphe J: Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. Cochrane Database Syst Rev. 2005 Jul 20;(3):CD003548. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16034903 # Jackson RD, LaCroix AZ, Gass M, Wallace RB, Robbins J, Lewis CE, Bassford T, Beresford SA, Black HR, Blanchette P, Bonds DE, Brunner RL, Brzyski RG, Caan B, Cauley JA, Chlebowski RT, Cummings SR, Granek I, Hays J, Heiss G, Hendrix SL, Howard BV, Hsia J, Hubbell FA, Johnson KC, Judd H, Kotchen JM, Kuller LH, Langer RD, Lasser NL, Limacher MC, Ludlam S, Manson JE, Margolis KL, McGowan J, Ockene JK, O'Sullivan MJ, Phillips L, Prentice RL, Sarto GE, Stefanick ML, Van Horn L, Wactawski-Wende J, Whitlock E, Anderson GL, Assaf AR, Barad D: Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med. 2006 Feb 16;354(7):669-83. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16481635 # Grant AM, Avenell A, Campbell MK, McDonald AM, MacLennan GS, McPherson GC, Anderson FH, Cooper C, Francis RM, Donaldson C, Gillespie WJ, Robinson CM, Torgerson DJ, Wallace WA: Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet. 2005 May 7-13;365(9471):1621-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15885294 # Porthouse J, Cockayne S, King C, Saxon L, Steele E, Aspray T, Baverstock M, Birks Y, Dumville J, Francis R, Iglesias C, Puffer S, Sutcliffe A, Watt I, Torgerson DJ: Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care. BMJ. 2005 Apr 30;330(7498):1003. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15860827
n3:group
nutraceutical
n3:indication
Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. It is vital in cell signaling, muscular contractions, bone health, and signalling cascades.
owl:sameAs
n7:DB01373 n8:DB01373
dcterms:title
Calcium
adms:identifier
n12:22984 n13:DB01373 n15:PA448718 n16:Calcium n17:C00076
n3:mechanismOfAction
Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. More than 500 human proteins are known to bind or transport calcium. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Parathyroid hormone (secreted from the parathyroid gland) regulates the resorption of Ca2+ from bone. Calcitonin stimulates incorporation of calcium in bone, although this process is largely independent of calcitonin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast. The currently recommended calcium intake is 1,500 milligrams per day for women not taking estrogen and 800 milligrams per day for women on estrogen. There is close to 300 milligrams of calcium in one cup of fluid milk. Calcium carbonate is currently the best and least expensive form of calcium supplement available.
n3:packager
n4:271B435F-363D-11E5-9242-09173F13E4C5 n4:271B4360-363D-11E5-9242-09173F13E4C5 n4:271B435D-363D-11E5-9242-09173F13E4C5 n4:271B435E-363D-11E5-9242-09173F13E4C5 n4:271B4366-363D-11E5-9242-09173F13E4C5 n4:271B4364-363D-11E5-9242-09173F13E4C5 n4:271B4365-363D-11E5-9242-09173F13E4C5 n4:271B435A-363D-11E5-9242-09173F13E4C5 n4:271B4362-363D-11E5-9242-09173F13E4C5 n4:271B4363-363D-11E5-9242-09173F13E4C5 n4:271B435B-363D-11E5-9242-09173F13E4C5 n4:271B435C-363D-11E5-9242-09173F13E4C5 n4:271B4361-363D-11E5-9242-09173F13E4C5
n3:routeOfElimination
The kidney excretes 250 mmol a day in urine, and resorbs 245 mmol, leading to a net loss in the urine of 5 mmol/d.
n9:hasAHFSCode
n10:56-12-00 n10:56-04-00 n10:88-08-00 n10:88-12-00 n10:88-29-00%2A n10:40-34-00%2A n10:34-00-00 n10:92-02-00%2A n10:40-18-17 n10:40-18-19 n10:40-12-00
n3:salt
n3:IUPAC-Name
n5:271B436B-363D-11E5-9242-09173F13E4C5
n3:InChI
n5:271B4371-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n5:271B4370-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n5:271B436D-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n5:271B436E-363D-11E5-9242-09173F13E4C5
n3:SMILES
n5:271B436F-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n5:271B4369-363D-11E5-9242-09173F13E4C5
n3:logP
n5:271B4367-363D-11E5-9242-09173F13E4C5 n5:271B436A-363D-11E5-9242-09173F13E4C5
n3:logS
n5:271B4368-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n5:271B4377-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n5:271B4378-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n5:271B4372-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n5:271B4373-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n5:271B4375-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n5:271B4374-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n5:271B4376-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
7440-70-2
n3:Bioavailability
n5:271B437B-363D-11E5-9242-09173F13E4C5
n3:Boiling-Point
n5:271B4380-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n5:271B437D-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n5:271B437E-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n5:271B437F-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n5:271B437A-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n5:271B4379-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n5:271B437C-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n5:271B436C-363D-11E5-9242-09173F13E4C5