This HTML5 document contains 49 embedded RDF statements represented using HTML+Microdata notation.

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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n19http://linked.opendata.cz/resource/drugbank/drug/DB01365/identifier/pubchem-substance/
n16http://linked.opendata.cz/resource/drugbank/drug/DB01365/identifier/drugbank/
n11http://linked.opendata.cz/resource/mesh/concept/
n9http://bio2rdf.org/drugbank:
n18http://linked.opendata.cz/resource/drugbank/drug/DB01365/identifier/chemspider/
admshttp://www.w3.org/ns/adms#
n12http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
owlhttp://www.w3.org/2002/07/owl#
n10http://linked.opendata.cz/ontology/mesh/
n5http://linked.opendata.cz/ontology/drugbank/
n7http://linked.opendata.cz/resource/drugbank/drug/DB01365/identifier/pharmgkb/
n6http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n17http://linked.opendata.cz/resource/drugbank/drug/DB01365/identifier/kegg-compound/
n4http://linked.opendata.cz/resource/drugbank/drug/DB01365/identifier/pubchem-compound/
n14http://linked.opendata.cz/resource/atc/
n13http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB01365
rdf:type
n5:Drug
n5:description
A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1248)
n5:group
approved
n5:halfLife
17 to 18 hours.
n5:indication
Used to maintain blood pressure in hypotensive states.
owl:sameAs
n9:DB01365 n12:DB01365
dcterms:title
Mephentermine
adms:identifier
n4:3677 n7:PA164745533 n16:DB01365 n17:C07889 n18:3549 n19:46505918
n5:mechanismOfAction
Mephentermine is an alpha adrenergic receptor agonist, but also acts indirectly by releasing endogenous norepinephrine. Cardiac output and systolic and diastolic pressures are usually increased. A change in heart rate is variable, depending on the degree of vagal tone. Sometimes the net vascular effect may be vasodilation. Large doses may depress the myocardium or produce central nervous system (CNS) effects.
n5:synonym
Mephentermine SID11112475
n5:salt
n10:hasConcept
n11:M0013430
n5:IUPAC-Name
n6:271B42D3-363D-11E5-9242-09173F13E4C5
n5:InChI
n6:271B42D9-363D-11E5-9242-09173F13E4C5
n5:Molecular-Formula
n6:271B42D8-363D-11E5-9242-09173F13E4C5
n5:Molecular-Weight
n6:271B42D5-363D-11E5-9242-09173F13E4C5
n5:Monoisotopic-Weight
n6:271B42D6-363D-11E5-9242-09173F13E4C5
n5:SMILES
n6:271B42D7-363D-11E5-9242-09173F13E4C5
n5:Water-Solubility
n6:271B42D1-363D-11E5-9242-09173F13E4C5
n5:logP
n6:271B42CF-363D-11E5-9242-09173F13E4C5 n6:271B42D2-363D-11E5-9242-09173F13E4C5
n5:logS
n6:271B42D0-363D-11E5-9242-09173F13E4C5
n13:hasATCCode
n14:C01CA11
n5:H-Bond-Acceptor-Count
n6:271B42DF-363D-11E5-9242-09173F13E4C5
n5:H-Bond-Donor-Count
n6:271B42E0-363D-11E5-9242-09173F13E4C5
n5:InChIKey
n6:271B42DA-363D-11E5-9242-09173F13E4C5
n5:Polar-Surface-Area--PSA-
n6:271B42DB-363D-11E5-9242-09173F13E4C5
n5:Polarizability
n6:271B42DD-363D-11E5-9242-09173F13E4C5
n5:Refractivity
n6:271B42DC-363D-11E5-9242-09173F13E4C5
n5:Rotatable-Bond-Count
n6:271B42DE-363D-11E5-9242-09173F13E4C5
n5:affectedOrganism
Humans and other mammals
n5:casRegistryNumber
100-92-5
n5:category
n5:Bioavailability
n6:271B42E4-363D-11E5-9242-09173F13E4C5
n5:Ghose-Filter
n6:271B42E6-363D-11E5-9242-09173F13E4C5
n5:MDDR-Like-Rule
n6:271B42E7-363D-11E5-9242-09173F13E4C5
n5:Melting-Point
n6:271B42E8-363D-11E5-9242-09173F13E4C5
n5:Number-of-Rings
n6:271B42E3-363D-11E5-9242-09173F13E4C5
n5:Physiological-Charge
n6:271B42E2-363D-11E5-9242-09173F13E4C5
n5:Rule-of-Five
n6:271B42E5-363D-11E5-9242-09173F13E4C5
n5:Traditional-IUPAC-Name
n6:271B42D4-363D-11E5-9242-09173F13E4C5
n5:pKa--strongest-basic-
n6:271B42E1-363D-11E5-9242-09173F13E4C5