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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n15http://linked.opendata.cz/resource/drugbank/drug/DB01357/identifier/wikipedia/
n8http://linked.opendata.cz/resource/drugbank/drug/DB01357/identifier/pharmgkb/
n11http://linked.opendata.cz/resource/drugbank/drug/DB01357/identifier/kegg-compound/
n14http://bio2rdf.org/drugbank:
n12http://linked.opendata.cz/resource/drugbank/drug/DB01357/identifier/kegg-drug/
n6http://linked.opendata.cz/resource/drugbank/drug/DB01357/identifier/drugbank/
admshttp://www.w3.org/ns/adms#
n10http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n7http://linked.opendata.cz/resource/drugbank/drug/DB01357/identifier/chebi/

Statements

Subject Item
n2:DB01357
rdf:type
n3:Drug
n3:description
The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives. [PubChem]
n3:group
approved
n3:indication
Mestranol was used as one of the first oral contraceptives.
owl:sameAs
n10:DB01357 n14:DB01357
dcterms:title
Mestranol
adms:identifier
n6:DB01357 n7:6784 n8:PA450388 n11:C07618 n12:D00575 n15:Mestranol
n3:mechanismOfAction
Mestranol is the 3-methyl ether of ethinylestradiol. Ethinylestradiol, is a synthetic derivative of estradiol. Ethinylestradiol is orally bio-active and the estrogen used in almost all modern formulations of combined oral contraceptive pills. It binds to (and activates) the estrogen receptor. Mestranol is a biologically inactive prodrug of ethinylestradiol to which it is demethylated in the liver with a conversion efficiency of 70%. Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).
n3:IUPAC-Name
n4:271B4211-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B4217-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B4216-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B4213-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B4214-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B4215-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B420F-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B4210-363D-11E5-9242-09173F13E4C5 n4:271B420D-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B420E-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n4:271B421D-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B421E-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B4218-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B4219-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B421B-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B421A-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B421C-363D-11E5-9242-09173F13E4C5
n3:casRegistryNumber
72-33-3
n3:Bioavailability
n4:271B4223-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B4225-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B4226-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B4227-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B4222-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B4221-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B4224-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B4212-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B421F-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B4220-363D-11E5-9242-09173F13E4C5