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Namespace Prefixes

PrefixIRI
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n13http://linked.opendata.cz/resource/atc/
n12http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB01336
rdf:type
n3:Drug
n3:description
Dimethyltubocurarinium (INN) or metocurine (USAN), also known as dimethyltubocurarine, is a non-depolarizing muscle relaxant. Patients on chronic anticonvulsant drugs are relatively resistant to metocurine.(PMID: 9915319)
n3:generalReferences
# Spacek A, Neiger FX, Krenn CG, Hoerauf K, Kress HG: Rocuronium-induced neuromuscular block is affected by chronic carbamazepine therapy. Anesthesiology. 1999 Jan;90(1):109-12. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9915319
n3:group
approved
n3:indication
Metocurine is a muscle relaxant.
owl:sameAs
n7:DB01336 n11:DB01336
dcterms:title
Metocurine
adms:identifier
n9:50094708 n10:Dimethyltubocurarinium n14:C07919 n15:21233 n16:19961 n17:DB01336 n18:46508044
n3:mechanismOfAction
Metocurine antagonizes the neurotransmitter action of acetylcholine by binding competitively with cholinergic receptor sites on the motor end-plate. This antagonism is inhibited, and neuromuscular block reversed, by acetylcholinesterase inhibitors such as neostigmine, edrophonium, and pyridostigmine.
n3:synonym
Dimethyltubocurarine
n3:IUPAC-Name
n4:271B3FBC-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B3FC2-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B3FC1-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B3FBE-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B3FBF-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B3FC0-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B3FBA-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B3FB8-363D-11E5-9242-09173F13E4C5 n4:271B3FBB-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B3FB9-363D-11E5-9242-09173F13E4C5
n12:hasATCCode
n13:M03AA04
n3:H-Bond-Acceptor-Count
n4:271B3FC8-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B3FC9-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B3FC3-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B3FC4-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B3FC6-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B3FC5-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B3FC7-363D-11E5-9242-09173F13E4C5
n3:casRegistryNumber
5152-30-7
n3:Bioavailability
n4:271B3FCE-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B3FD0-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B3FD1-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B3FCD-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B3FCC-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B3FCF-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B3FBD-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B3FCA-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B3FCB-363D-11E5-9242-09173F13E4C5