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Namespace Prefixes

PrefixIRI
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n24http://linked.opendata.cz/resource/drugbank/drug/DB01333/identifier/chemspider/
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Statements

Subject Item
n2:DB01333
rdf:type
n3:Drug
n3:description
A semi-synthetic cephalosporin antibiotic. [PubChem]
n3:generalReferences
# Neiss ES: Cephradine--a summary of preclinical studies and clinical pharmacology. J Ir Med Assoc. 1973 Mar 24;Suppl:1-12. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/4572639
n3:group
approved
owl:sameAs
n18:DB01333 n22:DB01333
dcterms:title
Cefradine
adms:identifier
n6:Cefradine n7:PA448890 n8:38103 n9:46505082 n10:D00264 n13:0003-0113-24 n14:DB01333 n15:C06897 n23:3547 n24:34933
n3:mechanismOfAction
Cefradine is a first generation cephalosporin antibiotic with a spectrum of activity similar to Cefalexin. Cefradine, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Cefradine interferes with an autolysin inhibitor.
n3:packager
n16:271B3F99-363D-11E5-9242-09173F13E4C5 n16:271B3F9A-363D-11E5-9242-09173F13E4C5 n16:271B3F97-363D-11E5-9242-09173F13E4C5 n16:271B3F98-363D-11E5-9242-09173F13E4C5 n16:271B3F9B-363D-11E5-9242-09173F13E4C5 n16:271B3F95-363D-11E5-9242-09173F13E4C5 n16:271B3F96-363D-11E5-9242-09173F13E4C5 n16:271B3F94-363D-11E5-9242-09173F13E4C5
n3:routeOfElimination
Over 90 percent of the drug is excreted unchanged in the urine within six hours.
n3:synonym
Cefradine CED 7-(D-2-Amino-2-(1,4-cyclohexadienyl)acetamide)desacetoxycephalosporanicacid Cefradinum Cephradine Sefril (6R,7R)-7-{[(2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Anspor Eskacef Cephradin Cefradina (6R,7R)-7-((R)-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid Velosef
n3:synthesisReference
Dennis Heemskerk, Anja Gerarda Hogenboom, Carlos Lenhardt, Harold Moody, Theodorus Johannes Godfried Maria Dooren, "Process for the preparation of cephradine." U.S. Patent US20060189802, issued August 24, 2006.
n20:hasConcept
n21:M0003834
n3:IUPAC-Name
n4:271B3FA0-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B3FA6-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B3FA5-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B3FA2-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B3FA3-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B3FA4-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B3F9E-363D-11E5-9242-09173F13E4C5 n4:271B3FB6-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B3F9C-363D-11E5-9242-09173F13E4C5 n4:271B3F9F-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B3F9D-363D-11E5-9242-09173F13E4C5
n11:hasATCCode
n12:J01DB09
n3:H-Bond-Acceptor-Count
n4:271B3FAC-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B3FAD-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B3FA7-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B3FA8-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B3FAA-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B3FA9-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B3FAB-363D-11E5-9242-09173F13E4C5
n3:casRegistryNumber
38821-53-3
n3:category
n3:Bioavailability
n4:271B3FB2-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B3FB4-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B3FB5-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B3FB7-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B3FB1-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B3FB0-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B3FB3-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B3FA1-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B3FAE-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B3FAF-363D-11E5-9242-09173F13E4C5