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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n5http://linked.opendata.cz/resource/drugbank/drug/DB01297/identifier/chebi/
n14http://linked.opendata.cz/resource/mesh/concept/
n17http://linked.opendata.cz/resource/drugbank/drug/DB01297/identifier/wikipedia/
n16http://linked.opendata.cz/resource/drugbank/drug/DB01297/identifier/pharmgkb/
n19http://linked.opendata.cz/resource/drugbank/drug/DB01297/identifier/kegg-compound/
n18http://bio2rdf.org/drugbank:
admshttp://www.w3.org/ns/adms#
n10http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
n4http://linked.opendata.cz/resource/drugbank/drug/DB01297/identifier/kegg-drug/
n8http://linked.opendata.cz/resource/drugbank/drug/DB01297/identifier/drugbank/
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owlhttp://www.w3.org/2002/07/owl#
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n6http://linked.opendata.cz/ontology/drugbank/
n7http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n12http://linked.opendata.cz/resource/atc/
n11http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB01297
rdf:type
n6:Drug
n6:description
A beta-adrenergic antagonist that has been used in the emergency treatment of cardiac arrhythmias. [PubChem]
n6:group
approved
n6:indication
Used in the emergency treatment of cardiac arrhythmias.
owl:sameAs
n10:DB01297 n18:DB01297
dcterms:title
Practolol
adms:identifier
n4:D05587 n5:258351 n8:DB01297 n16:PA164752820 n17:Practolol n19:C11696
n6:mechanismOfAction
Like other beta-adrenergic antagonists, practolol competes with adrenergic neurotransmitters such as catecholamines for binding at sympathetic receptor sites. Like propranolol and timolol, practolol binds at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting the effects of the catecholamines epinephrine and norepinephrine and decreasing heart rate, cardiac output, and systolic and diastolic blood pressure.
n6:synonym
Practololum N-(4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)acetamide Tocris-0831 (+-)-Practolol 1-(4-Acetamidophenoxy)-3-isopropylamino-2-propanol 4'-(2-Hydroxy-3-(isopropylamino)propoxy)acetanilide
n6:toxicity
Symptoms of overdose include abdominal irritation, central nervous system depression, coma, extremely slow heartbeat, heart failure, lethargy, low blood pressure, and wheezing.
n6:foodInteraction
Avoid natural licorice. Avoid alcohol.
n13:hasConcept
n14:M0017428
n6:IUPAC-Name
n7:271B6402-363D-11E5-9242-09173F13E4C5
n6:InChI
n7:271B6408-363D-11E5-9242-09173F13E4C5
n6:Molecular-Formula
n7:271B6407-363D-11E5-9242-09173F13E4C5
n6:Molecular-Weight
n7:271B6404-363D-11E5-9242-09173F13E4C5
n6:Monoisotopic-Weight
n7:271B6405-363D-11E5-9242-09173F13E4C5
n6:SMILES
n7:271B6406-363D-11E5-9242-09173F13E4C5
n6:Water-Solubility
n7:271B6400-363D-11E5-9242-09173F13E4C5
n6:logP
n7:271B6419-363D-11E5-9242-09173F13E4C5 n7:271B63FE-363D-11E5-9242-09173F13E4C5 n7:271B6401-363D-11E5-9242-09173F13E4C5
n6:logS
n7:271B63FF-363D-11E5-9242-09173F13E4C5
n11:hasATCCode
n12:C07AB01
n6:H-Bond-Acceptor-Count
n7:271B640E-363D-11E5-9242-09173F13E4C5
n6:H-Bond-Donor-Count
n7:271B640F-363D-11E5-9242-09173F13E4C5
n6:InChIKey
n7:271B6409-363D-11E5-9242-09173F13E4C5
n6:Polar-Surface-Area--PSA-
n7:271B640A-363D-11E5-9242-09173F13E4C5
n6:Polarizability
n7:271B640C-363D-11E5-9242-09173F13E4C5
n6:Refractivity
n7:271B640B-363D-11E5-9242-09173F13E4C5
n6:Rotatable-Bond-Count
n7:271B640D-363D-11E5-9242-09173F13E4C5
n6:caco2-Permeability
n7:271B641A-363D-11E5-9242-09173F13E4C5
n6:casRegistryNumber
6673-35-4
n6:category
n6:Bioavailability
n7:271B6414-363D-11E5-9242-09173F13E4C5
n6:Ghose-Filter
n7:271B6416-363D-11E5-9242-09173F13E4C5
n6:MDDR-Like-Rule
n7:271B6417-363D-11E5-9242-09173F13E4C5
n6:Melting-Point
n7:271B6418-363D-11E5-9242-09173F13E4C5
n6:Number-of-Rings
n7:271B6413-363D-11E5-9242-09173F13E4C5
n6:Physiological-Charge
n7:271B6412-363D-11E5-9242-09173F13E4C5
n6:Rule-of-Five
n7:271B6415-363D-11E5-9242-09173F13E4C5
n6:Traditional-IUPAC-Name
n7:271B6403-363D-11E5-9242-09173F13E4C5
n6:pKa--strongest-acidic-
n7:271B6410-363D-11E5-9242-09173F13E4C5
n6:pKa--strongest-basic-
n7:271B6411-363D-11E5-9242-09173F13E4C5