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Statements

Subject Item
n2:DB01285
rdf:type
n3:Drug
n3:description
Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis.
n3:group
approved
n3:halfLife
About 15 minutes following intravenous administration.
n3:indication
For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency.
owl:sameAs
n11:DB01285 n20:DB01285
dcterms:title
Corticotropin
adms:identifier
n9:Adrenocorticotropic_hormone n14:D00146 n15:PA449129 n16:DB01285 n17:C02017
n3:mechanismOfAction
As a diagnostic aid (adrenocortical function), corticotropin combines with a specific receptor on the adrenal cell plasma membrane. In patients with normal adrenocortical function, it stimulates the initial reaction involved in the synthesis of adrenal steroids (including cortisol, cortisone, weak androgenic substances, and a limited quantity of aldosterone) from cholesterol by increasing the quantity of cholesterol within the mitochondria. Corticotropin does not significantly increase serum cortisol concentrations in patients with primary adrenocortical insufficiency (Addison's disease). The mechanism of action of corticotropin in the treatment of infantile myoclonic seizures is unknown.
n3:packager
n19:271B6302-363D-11E5-9242-09173F13E4C5 n19:271B6303-363D-11E5-9242-09173F13E4C5
n3:synonym
ACTH Adrenocorticotropic hormone
n3:synthesisReference
Wylie W. Vale, Jr., Mary P. Stenzel-Poore, "Corticotropin-releasing factor overproducing transgenic mice." U.S. Patent US6023011, issued June, 1993.
n12:hasConcept
n13:M0000499
foaf:page
n7:corticotropin-gel.html
n3:Molecular-Formula
n5:271B6307-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n5:271B6306-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n5:271B6305-363D-11E5-9242-09173F13E4C5
n21:hasATCCode
n22:H01AA01
n3:absorption
Corticotropin is rapidly absorbed following intramuscular administration; the repository dosage form is slowly absorbed over approximately 8 to 16 hours.
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
9002-60-2
n3:category
n3:containedIn
n4:271B6304-363D-11E5-9242-09173F13E4C5