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Namespace Prefixes

PrefixIRI
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n14http://linked.opendata.cz/resource/drugbank/drug/DB01199/identifier/pubchem-substance/
n11http://linked.opendata.cz/resource/drugbank/drug/DB01199/identifier/drugbank/
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n20http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
n10http://linked.opendata.cz/resource/drugbank/drug/DB01199/identifier/chemspider/
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n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n8http://linked.opendata.cz/resource/drugbank/drug/DB01199/identifier/wikipedia/
n9http://linked.opendata.cz/resource/drugbank/drug/DB01199/identifier/pharmgkb/
n19http://linked.opendata.cz/resource/atc/
n5http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB01199
rdf:type
n3:Drug
n3:description
A neuromuscular blocker and active ingredient in curare; plant based alkaloid of Menispermaceae. [PubChem]
n3:group
approved
n3:halfLife
1-2 hours
n3:indication
Used as a diagnosis agent for myasthenia gravis, and also to facilitate the intubation after induction of anesthesia in surgical procedure
owl:sameAs
n16:DB01199 n20:DB01199
dcterms:title
Tubocurarine
adms:identifier
n8:Tubocurarine n9:PA451811 n10:5778 n11:DB01199 n13:6000 n14:46505279 n18:9774
n3:mechanismOfAction
Tubocurarine, the chief alkaloid in tobacco products, binds stereo-selectively to nicotinic-cholinergic receptors at the autonomic ganglia, in the adrenal medulla, at neuromuscular junctions, and in the brain. Two types of central nervous system effects are believed to be the basis of Tubocurarine's positively reinforcing properties. A stimulating effect is exerted mainly in the cortex via the locus ceruleus and a reward effect is exerted in the limbic system. At low doses the stimulant effects predominate while at high doses the reward effects predominate. Intermittent intravenous administration of Tubocurarine activates neurohormonal pathways, releasing acetylcholine, norepinephrine, dopamine, serotonin, vasopressin, beta-endorphin, growth hormone, and ACTH.
n3:packager
n17:271B542F-363D-11E5-9242-09173F13E4C5
n3:synonym
7',12'-Dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraranium d-tubocurarine Tubocurarin (+)-tubocurarine
n5:hasAHFSCode
n6:12-20-00
n3:salt
n22:hasConcept
n23:M0022137
n3:IUPAC-Name
n4:271B5435-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B543B-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B543A-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B5437-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B5438-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B5439-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B5433-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B5434-363D-11E5-9242-09173F13E4C5 n4:271B5431-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B5432-363D-11E5-9242-09173F13E4C5
n5:hasATCCode
n19:M03AA02
n3:H-Bond-Acceptor-Count
n4:271B5441-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B5442-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B543C-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B543D-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B543F-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B543E-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B5440-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
6989-98-6
n3:category
n3:containedIn
n12:271B5430-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n4:271B5447-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B5449-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B544A-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B5446-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B5445-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B5448-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B5436-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B5443-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B5444-363D-11E5-9242-09173F13E4C5