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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n17http://linked.opendata.cz/resource/mesh/concept/
foafhttp://xmlns.com/foaf/0.1/
n15http://linked.opendata.cz/resource/drugbank/drug/DB01191/identifier/chebi/
n18http://linked.opendata.cz/resource/drugbank/drug/DB01191/identifier/wikipedia/
n10http://bio2rdf.org/drugbank:
n12http://linked.opendata.cz/resource/drugbank/drug/DB01191/identifier/pharmgkb/
admshttp://www.w3.org/ns/adms#
n6http://www.rxlist.com/cgi/generic/
n19http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
owlhttp://www.w3.org/2002/07/owl#
n16http://linked.opendata.cz/ontology/mesh/
n3http://linked.opendata.cz/ontology/drugbank/
n14http://linked.opendata.cz/resource/drugbank/drug/DB01191/identifier/kegg-drug/
n13http://linked.opendata.cz/resource/drugbank/drug/DB01191/identifier/drugbank/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n8http://linked.opendata.cz/resource/atc/
n7http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB01191
rdf:type
n3:Drug
n3:description
Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. It was for some years in the mid-1990s approved by the United States Food and Drug Administration for the purposes of weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was withdrawn.
n3:group
approved illicit withdrawn
n3:halfLife
17-20 hours
n3:indication
For the management of obesity including weight loss and maintenance of weight loss in patients on a reduced calorie diet
owl:sameAs
n10:DB01191 n19:DB01191
dcterms:title
Dexfenfluramine
adms:identifier
n12:PA164747936 n13:DB01191 n14:D07805 n15:439329 n18:Dexfenfluramine
n3:mechanismOfAction
Dexfenfluramine binds to the serotonin reuptake pump. This causes inhbition of serotonin reuptake. The increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates.
n3:synonym
(S)-N-Ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine (+)-fenfluramine Dexfenfluraminum D-N-Ethyl-alpha-methyl-m-trifluoromethylphenethylamine Dextrofenfluramine Dexfenfluramina Dexfenfluramine (S)-fenfluramine
n3:toxicity
Symptoms of overdose include respiratory failure and cardiac arrest leading to death.
n3:foodInteraction
Take with meals.
n3:proteinBinding
36%
n16:hasConcept
n17:M0030010
foaf:page
n6:dexfen.htm
n3:IUPAC-Name
n4:271B525A-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B5260-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B525F-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B525C-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B525D-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B525E-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B5258-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B5259-363D-11E5-9242-09173F13E4C5 n4:271B5256-363D-11E5-9242-09173F13E4C5 n4:271B526F-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B5257-363D-11E5-9242-09173F13E4C5
n7:hasATCCode
n8:A08AA04
n3:H-Bond-Acceptor-Count
n4:271B5266-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B5267-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B5261-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B5262-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B5264-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B5263-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B5265-363D-11E5-9242-09173F13E4C5
n3:absorption
Well-absorbed from the gastrointestinal tract.
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
3239-44-9
n3:category
n3:Bioavailability
n4:271B526B-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B526D-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B526E-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B526A-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B5269-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B526C-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B525B-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B5268-363D-11E5-9242-09173F13E4C5