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Namespace Prefixes

PrefixIRI
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Statements

Subject Item
n2:DB01189
rdf:type
n3:Drug
n3:description
Desflurane is a highly fluorinated methyl ethyl ether used for maintenance of general anaesthesia. Volatile agents such as desflurane may activate GABA channels and hyperpolarize cell membranes. In addition, they may inhibit certain calcium channels and therefore prevent release of neurotransmitters and inhibit glutamate channels. Volatile anesthetics easily partition into cellular membranes and could expand the volume of the cell membrane and subsequently distort channels necessary for sodium ion flux and the development of action potentials necessary for synaptic transmission. Desflurane preconditions human myocardium against ischemia through activation of mitochondrial K(ATP) channels, adenosine A1 receptor, and alpha and beta adrenoceptors.
n3:dosage
n8:271B5177-363D-11E5-9242-09173F13E4C5 n8:271B5178-363D-11E5-9242-09173F13E4C5
n3:group
approved
n3:indication
For use as an inhalation agent for induction and/or maintenance of anesthesia for inpatient and outpatient surgery in adults.
owl:sameAs
n14:DB01189 n31:DB01189
dcterms:title
Desflurane
adms:identifier
n18:42113 n19:46505270 n20:10019-641-24 n21:C07519 n22:D00546 n23:DB01189 n26:4445 n27:38403 n29:PA164749136 n30:Desflurane
n3:mechanismOfAction
Desflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Desflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Desflurane also binds to and agonizes the GABA receptor, the large conductance Ca<sup>2+</sup> activated potassium channel, the glycine receptors, and antagonizes the glutamate receptors.
n3:packager
n25:271B5174-363D-11E5-9242-09173F13E4C5 n25:271B5175-363D-11E5-9242-09173F13E4C5
n3:patent
n12:5617906
n3:synonym
Desflurano Difluoromethyl 1,2,2,2-tetrafluoroethyl ether (+-)-2-Difluoromethyl 1,2,2,2-tetrafluoroethyl ether Suprane 1,1,1,2-Tetrafluoro-2-(difluoromethoxy)ethane Desfluranum Desflurane
n15:hasAHFSCode
n28:28-04-00
n3:synthesisReference
Leonid A. Rozov, Chialang Huang, Gerald G. Vernice, "Synthesis of desflurane." U.S. Patent US5205914, issued June, 1991.
n10:hasConcept
n11:M0151698
foaf:page
n7:desflurane-inhalation-oral-nebulization.html n9:desflurane.htm
n3:IUPAC-Name
n5:271B517D-363D-11E5-9242-09173F13E4C5
n3:InChI
n5:271B5183-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n5:271B5182-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n5:271B517F-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n5:271B5180-363D-11E5-9242-09173F13E4C5
n3:SMILES
n5:271B5181-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n5:271B5193-363D-11E5-9242-09173F13E4C5 n5:271B517B-363D-11E5-9242-09173F13E4C5
n3:logP
n5:271B5195-363D-11E5-9242-09173F13E4C5 n5:271B5179-363D-11E5-9242-09173F13E4C5 n5:271B517C-363D-11E5-9242-09173F13E4C5
n3:logS
n5:271B517A-363D-11E5-9242-09173F13E4C5
n15:hasATCCode
n16:N01AB07
n3:H-Bond-Acceptor-Count
n5:271B5189-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n5:271B518A-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n5:271B5184-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n5:271B5185-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n5:271B5187-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n5:271B5186-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n5:271B5188-363D-11E5-9242-09173F13E4C5
n3:absorption
Rapidly absorbed into the circulation via the lungs following inhalation.
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
57041-67-5
n3:category
n3:containedIn
n4:271B5176-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n5:271B518F-363D-11E5-9242-09173F13E4C5
n3:Boiling-Point
n5:271B5194-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n5:271B5191-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n5:271B5192-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n5:271B518E-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n5:271B518D-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n5:271B5190-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n5:271B517E-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n5:271B518B-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n5:271B518C-363D-11E5-9242-09173F13E4C5