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Namespace Prefixes

PrefixIRI
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dctermshttp://purl.org/dc/terms/
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n12http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB01159
rdf:type
n5:Drug
n5:description
A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)
n5:dosage
n28:271B4B9B-363D-11E5-9242-09173F13E4C5
n5:generalReferences
# Bovill JG: Inhalation anaesthesia: from diethyl ether to xenon. Handb Exp Pharmacol. 2008;(182):121-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18175089
n5:group
approved
n5:indication
For the induction and maintenance of general anesthesia
owl:sameAs
n19:DB01159 n22:DB01159
dcterms:title
Halothane
adms:identifier
n8:46506589 n9:Halothane n10:PA449845 n11:3562 n14:0409-4894-02 n15:HLT n16:C07515 n17:D00542 n21:2401 n23:2401 n25:DB01159 n26:5615 n27:3441
n5:mechanismOfAction
Halothane causes general anaethesia due to its actions on multiple ion channels, which ultimately depresses nerve conduction, breathing, cardiac contractility. Its immobilizing effects have been attributed to its binding to potassium channels in cholinergic neurons. Halothane's effect are also likely due to binding to NMDA and calcium channels, causing hyperpolarization.
n5:packager
n29:271B4B98-363D-11E5-9242-09173F13E4C5 n29:271B4B99-363D-11E5-9242-09173F13E4C5
n5:synonym
Halotano Fluothane Bromochlorotrifluoroethane Phthorothanum Halothane 1-Bromo-1-chloro-2,2,2-trifluoroethane 2-Bromo-2-Chloro-1,1,1-Trifluoroethane 1,1,1-Trifluoro-2-chloro-2-bromoethane Rhodialothan Halothanum 2,2,2-Trifluoro-1-chloro-1-bromoethane Narcotane Ftorotan 1,1,1-Trifluoro-2-bromo-2-chloroethane
n5:toxicity
Toxic effects of halothane include malignant hyperthermia and hepatitis.
n12:hasAHFSCode
n13:28-04-00
n5:synthesisReference
U.S. Patents 2,849,502, 2,921,098, 2,959,624, 3,082,263.
n3:hasConcept
n4:M0009773
foaf:page
n32:halothane.htm
n5:IUPAC-Name
n6:271B4BA0-363D-11E5-9242-09173F13E4C5
n5:InChI
n6:271B4BA6-363D-11E5-9242-09173F13E4C5
n5:Molecular-Formula
n6:271B4BA5-363D-11E5-9242-09173F13E4C5
n5:Molecular-Weight
n6:271B4BA2-363D-11E5-9242-09173F13E4C5
n5:Monoisotopic-Weight
n6:271B4BA3-363D-11E5-9242-09173F13E4C5
n5:SMILES
n6:271B4BA4-363D-11E5-9242-09173F13E4C5
n5:Water-Solubility
n6:271B4B9E-363D-11E5-9242-09173F13E4C5 n6:271B4BB4-363D-11E5-9242-09173F13E4C5
n5:logP
n6:271B4B9C-363D-11E5-9242-09173F13E4C5 n6:271B4B9F-363D-11E5-9242-09173F13E4C5 n6:271B4BB7-363D-11E5-9242-09173F13E4C5
n5:logS
n6:271B4B9D-363D-11E5-9242-09173F13E4C5 n6:271B4BB8-363D-11E5-9242-09173F13E4C5
n12:hasATCCode
n30:N01AB01
n5:H-Bond-Acceptor-Count
n6:271B4BAC-363D-11E5-9242-09173F13E4C5
n5:H-Bond-Donor-Count
n6:271B4BAD-363D-11E5-9242-09173F13E4C5
n5:InChIKey
n6:271B4BA7-363D-11E5-9242-09173F13E4C5
n5:Polar-Surface-Area--PSA-
n6:271B4BA8-363D-11E5-9242-09173F13E4C5
n5:Polarizability
n6:271B4BAA-363D-11E5-9242-09173F13E4C5
n5:Refractivity
n6:271B4BA9-363D-11E5-9242-09173F13E4C5
n5:Rotatable-Bond-Count
n6:271B4BAB-363D-11E5-9242-09173F13E4C5
n5:affectedOrganism
Humans and other mammals
n5:casRegistryNumber
151-67-7
n5:category
n5:containedIn
n20:271B4B9A-363D-11E5-9242-09173F13E4C5
n5:Bioavailability
n6:271B4BB0-363D-11E5-9242-09173F13E4C5
n5:Boiling-Point
n6:271B4BB6-363D-11E5-9242-09173F13E4C5
n5:Ghose-Filter
n6:271B4BB2-363D-11E5-9242-09173F13E4C5
n5:MDDR-Like-Rule
n6:271B4BB3-363D-11E5-9242-09173F13E4C5
n5:Melting-Point
n6:271B4BB5-363D-11E5-9242-09173F13E4C5
n5:Number-of-Rings
n6:271B4BAF-363D-11E5-9242-09173F13E4C5
n5:Physiological-Charge
n6:271B4BAE-363D-11E5-9242-09173F13E4C5
n5:Rule-of-Five
n6:271B4BB1-363D-11E5-9242-09173F13E4C5
n5:Traditional-IUPAC-Name
n6:271B4BA1-363D-11E5-9242-09173F13E4C5