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Namespace Prefixes

PrefixIRI
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n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
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n14http://linked.opendata.cz/resource/drugbank/dosage/
n20http://linked.opendata.cz/resource/drugbank/drug/DB01153/identifier/national-drug-code-directory/
n24http://bio2rdf.org/drugbank:
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owlhttp://www.w3.org/2002/07/owl#
n25http://linked.opendata.cz/ontology/mesh/
n3http://linked.opendata.cz/ontology/drugbank/
n27http://www.drugs.com/cdi/
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n4http://linked.opendata.cz/resource/drugbank/property/
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xsdhhttp://www.w3.org/2001/XMLSchema#
n8http://linked.opendata.cz/resource/atc/
n7http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB01153
rdf:type
n3:Drug
n3:description
Sertaconazole nitrate is an antifungal medication of the imidazole class. It is available as a cream to treat skin infections such as athlete's foot. [Wikipedia]
n3:dosage
n14:271B4A6E-363D-11E5-9242-09173F13E4C5
n3:group
approved
n3:indication
For the topical treatment of interdigital tinea pedis in immunocompetent patients 12 years of age and older, caused by <i>Trichophyton rubrum</i>, <i>Trichophyton mentagrophytes</i>, and <i>Epidermophyton floccosum</i>.
owl:sameAs
n17:DB01153 n24:DB01153
dcterms:title
Sertaconazole
adms:identifier
n13:PA164748328 n15:Sertaconazole n18:65863 n19:46507290 n20:0062-1650-03 n21:59273 n23:DB01153
n3:mechanismOfAction
Sertaconazole interacts with 14-&alpha; demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Sertaconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
n3:packager
n5:271B4A6B-363D-11E5-9242-09173F13E4C5
n3:patent
n22:5135943
n3:synonym
Sertaconazolum Sertaconazole Demofix Sertaconazol Ertaczo
n3:proteinBinding
>99% to plasma
n25:hasConcept
n26:M0169568
foaf:page
n10:ertaczo.htm n27:sertaconazole.html
n3:IUPAC-Name
n4:271B4A73-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B4A79-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B4A78-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B4A75-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B4A76-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B4A77-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B4A88-363D-11E5-9242-09173F13E4C5 n4:271B4A71-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B4A89-363D-11E5-9242-09173F13E4C5 n4:271B4A6F-363D-11E5-9242-09173F13E4C5 n4:271B4A72-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B4A70-363D-11E5-9242-09173F13E4C5
n7:hasATCCode
n8:G01AF19 n8:D01AC14
n3:H-Bond-Acceptor-Count
n4:271B4A7F-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B4A80-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B4A7A-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B4A7B-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B4A7D-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B4A7C-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B4A7E-363D-11E5-9242-09173F13E4C5
n3:absorption
Bioavailability is negligible.
n3:affectedOrganism
Yeast and other fungi
n3:casRegistryNumber
99592-32-2
n3:category
n3:containedIn
n6:271B4A6D-363D-11E5-9242-09173F13E4C5 n6:271B4A6C-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n4:271B4A84-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B4A86-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B4A87-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B4A83-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B4A82-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B4A85-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B4A74-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B4A81-363D-11E5-9242-09173F13E4C5