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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n6http://linked.opendata.cz/resource/drugbank/drug/DB01152/identifier/chemspider/
n9http://bio2rdf.org/drugbank:
n15http://linked.opendata.cz/resource/drugbank/drug/DB01152/identifier/wikipedia/
admshttp://www.w3.org/ns/adms#
n14http://linked.opendata.cz/resource/drugbank/drug/DB01152/identifier/pharmgkb/
n11http://linked.opendata.cz/resource/drugbank/drug/DB01152/identifier/kegg-compound/
n16http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n12http://linked.opendata.cz/resource/drugbank/drug/DB01152/identifier/pubchem-compound/
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n10http://linked.opendata.cz/resource/drugbank/drug/DB01152/identifier/pubchem-substance/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n7http://linked.opendata.cz/resource/drugbank/drug/DB01152/identifier/drugbank/

Statements

Subject Item
n2:DB01152
rdf:type
n3:Drug
n3:description
Candicidin is an antibiotic obtained from a streptomyces (Streptomyces griseus) and active against some fungi of the genus Candida (C. albicans). Candicidin is administered intravaginally in the treatment of vulvovaginal candidiasis.
n3:group
withdrawn
n3:indication
Used in the topical treatment of vulvovaginal candidiasis.
owl:sameAs
n9:DB01152 n16:DB01152
dcterms:title
Candicidin
adms:identifier
n6:10128184 n7:DB01152 n10:46504812 n11:C06690 n12:441142 n14:PA164754911 n15:Candicidin
n3:mechanismOfAction
Ergosterol, the principal sterol in the fungal cytoplasmic membrane, is the target site of action of Candicidin. Candicidin binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. There is some evidence that the binding site in the cell wall may be to fatty acids or fatty acid esters and that this binding capacity must be satisfied before candicidin can bring about its lethal effect by binding to sterol in the cell membrane.
n3:synthesisReference
Siminoff, P.; U.S. Patent 2,872,373; February 3,1959; assigned to S.B. Penick & Company, Inc. Waksman, S.A. and Lechevalier, H.A.; U.S. Patent 2,992,162; July 11,1961; assigned to Rutgers Research and Educational Foundation.
n3:IUPAC-Name
n4:271B4A54-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B4A5A-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B4A59-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B4A56-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B4A57-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B4A58-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B4A52-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B4A50-363D-11E5-9242-09173F13E4C5 n4:271B4A6A-363D-11E5-9242-09173F13E4C5 n4:271B4A53-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B4A51-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n4:271B4A60-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B4A61-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B4A5B-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B4A5C-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B4A5E-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B4A5D-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B4A5F-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Various Fungus Species
n3:casRegistryNumber
1403-17-4
n3:category
n3:Bioavailability
n4:271B4A66-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B4A68-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B4A69-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B4A65-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B4A64-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B4A67-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B4A55-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B4A62-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B4A63-363D-11E5-9242-09173F13E4C5