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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n25http://linked.opendata.cz/resource/AHFS/
foafhttp://xmlns.com/foaf/0.1/
n17http://linked.opendata.cz/resource/mesh/concept/
n24http://linked.opendata.cz/resource/drugbank/drug/DB01147/identifier/pubchem-substance/
n6http://linked.opendata.cz/resource/drugbank/company/
n21http://linked.opendata.cz/resource/drugbank/drug/DB01147/identifier/drugbank/
n12http://bio2rdf.org/drugbank:
n20http://linked.opendata.cz/resource/drugbank/drug/DB01147/identifier/chemspider/
admshttp://www.w3.org/ns/adms#
n15http://www.drugs.com/mtm/
n22http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
n18http://linked.opendata.cz/resource/drugbank/drug/DB01147/identifier/chebi/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n4http://linked.opendata.cz/resource/drugbank/medicinal-product/
owlhttp://www.w3.org/2002/07/owl#
n16http://linked.opendata.cz/ontology/mesh/
n3http://linked.opendata.cz/ontology/drugbank/
n5http://linked.opendata.cz/resource/drugbank/property/
n27http://linked.opendata.cz/resource/drugbank/drug/DB01147/identifier/pharmgkb/
n8http://linked.opendata.cz/resource/drugbank/drug/DB01147/identifier/wikipedia/
xsdhhttp://www.w3.org/2001/XMLSchema#
n26http://linked.opendata.cz/resource/drugbank/drug/DB01147/identifier/pdb/
n19http://linked.opendata.cz/resource/drugbank/drug/DB01147/identifier/kegg-compound/
n10http://linked.opendata.cz/resource/atc/
n23http://linked.opendata.cz/resource/drugbank/drug/DB01147/identifier/pubchem-compound/
n9http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB01147
rdf:type
n3:Drug
n3:description
A semi-synthetic antibiotic that is a chlorinated derivative of oxacillin. [PubChem]
n3:group
approved
n3:indication
Used to treat infections caused by penicillinase-producing staphylococci, including pneumococci, group A beta-hemolytic streptococci, and penicillin G-sensitive and penicillin G-resistant staphylococci.
owl:sameAs
n12:DB01147 n22:DB01147
dcterms:title
Cloxacillin
adms:identifier
n8:Cloxacillin n18:3765 n19:C06923 n20:5873 n21:DB01147 n23:6098 n24:46507109 n26:CXN n27:PA449059
n3:mechanismOfAction
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, cloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cloxacillin interferes with an autolysin inhibitor.
n3:packager
n6:271B4910-363D-11E5-9242-09173F13E4C5 n6:271B490E-363D-11E5-9242-09173F13E4C5 n6:271B490F-363D-11E5-9242-09173F13E4C5 n6:271B4911-363D-11E5-9242-09173F13E4C5 n6:271B4912-363D-11E5-9242-09173F13E4C5
n3:synonym
Cloxacillinum CLOXACILLIN Cloxacilina (2S,5R,6R)-6-({[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 6-(3-(O-Chlorophenyl)-5-methyl-4-isoxazolecarboxamido)penicillanic acid (3-(O-Chlorophenyl)-5-methyl-4-isoxazolyl)penicillin Cloxacilline
n3:toxicity
Oral LD<sub>50</sub> in rat and mouse is 5000 mg/kg. Intravenous LD<sub>50</sub> in rat is 1660 mg/kg. Symptoms of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, and swelling of face, lips, tongue, or throat.
n9:hasAHFSCode
n25:08-12-16-12
n3:foodInteraction
Take on an empty stomach.
n3:proteinBinding
95%
n3:salt
n3:synthesisReference
Doyle, F.P. and Nayler, J.H.C.; British Patent 905,778; September 12, 1962; assigned to Beecham Research Laboratories, Ltd. Doyle, F.P. and Nayler, J.H.C.; US. Patent 2,996,501; August 15, 1961.
n16:hasConcept
n17:M0004647
foaf:page
n15:cloxacillin.html
n3:IUPAC-Name
n5:271B4923-363D-11E5-9242-09173F13E4C5
n3:InChI
n5:271B4929-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n5:271B4928-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n5:271B4925-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n5:271B4926-363D-11E5-9242-09173F13E4C5
n3:SMILES
n5:271B4927-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n5:271B4939-363D-11E5-9242-09173F13E4C5 n5:271B4921-363D-11E5-9242-09173F13E4C5
n3:logP
n5:271B493A-363D-11E5-9242-09173F13E4C5 n5:271B491F-363D-11E5-9242-09173F13E4C5 n5:271B4922-363D-11E5-9242-09173F13E4C5
n3:logS
n5:271B4920-363D-11E5-9242-09173F13E4C5
n3:pKa
n5:271B493B-363D-11E5-9242-09173F13E4C5
n9:hasATCCode
n10:J01CF02
n3:H-Bond-Acceptor-Count
n5:271B492F-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n5:271B4930-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n5:271B492A-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n5:271B492B-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n5:271B492D-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n5:271B492C-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n5:271B492E-363D-11E5-9242-09173F13E4C5
n3:absorption
Well absorbed from the gastrointestinal tract.
n3:affectedOrganism
Enteric bacteria and other eubacteria
n3:casRegistryNumber
61-72-3
n3:category
n3:containedIn
n4:271B491E-363D-11E5-9242-09173F13E4C5 n4:271B491B-363D-11E5-9242-09173F13E4C5 n4:271B491D-363D-11E5-9242-09173F13E4C5 n4:271B491C-363D-11E5-9242-09173F13E4C5 n4:271B4919-363D-11E5-9242-09173F13E4C5 n4:271B491A-363D-11E5-9242-09173F13E4C5 n4:271B4917-363D-11E5-9242-09173F13E4C5 n4:271B4918-363D-11E5-9242-09173F13E4C5 n4:271B4915-363D-11E5-9242-09173F13E4C5 n4:271B4916-363D-11E5-9242-09173F13E4C5 n4:271B4913-363D-11E5-9242-09173F13E4C5 n4:271B4914-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n5:271B4935-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n5:271B4937-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n5:271B4938-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n5:271B4934-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n5:271B4933-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n5:271B4936-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n5:271B4924-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n5:271B4931-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n5:271B4932-363D-11E5-9242-09173F13E4C5