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Namespace Prefixes

PrefixIRI
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n13http://linked.opendata.cz/resource/drugbank/drug/DB01143/identifier/chebi/
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n27http://linked.opendata.cz/resource/drugbank/drug/DB01143/identifier/wikipedia/
n8http://linked.opendata.cz/resource/drugbank/drug/DB01143/identifier/pharmgkb/
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n29http://linked.opendata.cz/resource/atc/
n28http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB01143
rdf:type
n3:Drug
n3:description
A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. [PubChem]
n3:dosage
n23:271B488A-363D-11E5-9242-09173F13E4C5 n23:271B488B-363D-11E5-9242-09173F13E4C5
n3:generalReferences
# Santini V, Giles FJ: The potential of amifostine: from cytoprotectant to therapeutic agent. Haematologica. 1999 Nov;84(11):1035-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10553165
n3:group
approved investigational
n3:halfLife
8 minutes
n3:indication
For reduction in the cumulative renal toxicity in patients with ovarian cancer (using cisplatin) and moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.
owl:sameAs
n22:DB01143 n24:DB01143
dcterms:title
Amifostine
adms:identifier
n8:PA448365 n9:2141 n10:C06819 n11:58178-017-01 n12:DB01143 n13:2636 n14:2056 n26:46505305 n27:Amifostine
n3:mechanismOfAction
The thiol metabolite is responsible for most of the cytoprotective and radioprotective properties of amifostine. It is readily taken up by cells where it binds to and detoxifies reactive metabolites of platinum and alkylating agents as well as scavenges free radicals. Other possible effects include inhibition of apoptosis, alteration of gene expression and modification of enzyme activity.
n3:packager
n20:271B4886-363D-11E5-9242-09173F13E4C5 n20:271B4887-363D-11E5-9242-09173F13E4C5 n20:271B4884-363D-11E5-9242-09173F13E4C5 n20:271B4885-363D-11E5-9242-09173F13E4C5
n3:patent
n15:2120133 n15:5424471 n15:5994409
n3:routeOfElimination
After a 10-second bolus dose of 150 mg/m2 of ETHYOL, renal excretion of the parent drug and its two metabolites was low during the hour following drug administration, averaging 0.69%, 2.64% and 2.22% of the administered dose for the parent, thiol and disulfide, respectively.
n3:synonym
Amifostine Aminopropylaminoethyl Thiophosphate Gammaphos Ethyol Apaetp Ethiofos Amifostine Ethiofos Amifostina SAPEP Amifostinum WR-1065
n3:toxicity
Rat LD<sub>50</sub>: 826 mg/kg
n28:hasAHFSCode
n30:92-00-00
n3:synthesisReference
Paul E. Kennedy, Roger A. Rajewski, John M. Baldoni, "Crystalline amifostine compositions and methods of the preparation and use of same." U.S. Patent US5424471, issued April, 1979.
n16:hasConcept
n17:M0007867
foaf:page
n19:amifostine.htm n25:amifostine.html
n3:IUPAC-Name
n4:271B4890-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B4896-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B4895-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B4892-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B4893-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B4894-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B48A6-363D-11E5-9242-09173F13E4C5 n4:271B488E-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B48A7-363D-11E5-9242-09173F13E4C5 n4:271B488F-363D-11E5-9242-09173F13E4C5 n4:271B488C-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B488D-363D-11E5-9242-09173F13E4C5
n28:hasATCCode
n29:V03AF05
n3:H-Bond-Acceptor-Count
n4:271B489C-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B489D-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B4897-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B4898-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B489A-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B4899-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B489B-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
20537-88-6
n3:category
n3:containedIn
n5:271B4889-363D-11E5-9242-09173F13E4C5 n5:271B4888-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n4:271B48A2-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B48A4-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B48A5-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B48A1-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B48A0-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B48A3-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B4891-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B489E-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B489F-363D-11E5-9242-09173F13E4C5