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Namespace Prefixes

PrefixIRI
n22http://www.rxlist.com/cgi/generic3/
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n13http://linked.opendata.cz/resource/drugbank/drug/DB01099/identifier/bindingdb/
n18http://linked.opendata.cz/resource/drugbank/drug/DB01099/identifier/pubchem-compound/
foafhttp://xmlns.com/foaf/0.1/
n29http://linked.opendata.cz/resource/mesh/concept/
n20http://linked.opendata.cz/resource/drugbank/company/
n27http://linked.opendata.cz/resource/drugbank/dosage/
n19http://linked.opendata.cz/resource/drugbank/drug/DB01099/identifier/pubchem-substance/
n17http://linked.opendata.cz/resource/drugbank/drug/DB01099/identifier/kegg-drug/
n16http://linked.opendata.cz/resource/drugbank/drug/DB01099/identifier/drugbank/
n6http://bio2rdf.org/drugbank:
n14http://linked.opendata.cz/resource/drugbank/drug/DB01099/identifier/national-drug-code-directory/
admshttp://www.w3.org/ns/adms#
n12http://linked.opendata.cz/resource/drugbank/drug/DB01099/identifier/chemspider/
n7http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n26http://linked.opendata.cz/resource/drugbank/medicinal-product/
owlhttp://www.w3.org/2002/07/owl#
n28http://linked.opendata.cz/ontology/mesh/
n3http://linked.opendata.cz/ontology/drugbank/
n24http://www.drugs.com/cdi/
n11http://linked.opendata.cz/resource/drugbank/drug/DB01099/identifier/chebi/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n23http://linked.opendata.cz/resource/drugbank/drug/DB01099/identifier/wikipedia/
n15http://linked.opendata.cz/resource/drugbank/drug/DB01099/identifier/pharmgkb/
n9http://linked.opendata.cz/resource/atc/
n8http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB01099
rdf:type
n3:Drug
n3:description
A fluorinated cytosine analog that is used as an antifungal agent. [PubChem]
n3:dosage
n27:271B3EE5-363D-11E5-9242-09173F13E4C5 n27:271B3EE6-363D-11E5-9242-09173F13E4C5
n3:group
approved
n3:halfLife
2.4 to 4.8 hours.
n3:indication
For the treatment (in combination with amphotericin B) of serious infections caused by susceptible strains of Candida (septicemia, endocarditis and urinary system infections) and/or Cryptococcus (meningitis and pulmonary infections).
owl:sameAs
n6:DB01099 n7:DB01099
dcterms:title
Flucytosine
adms:identifier
n11:5100 n12:3249 n13:50241247 n14:0187-3554-10 n15:PA449654 n16:DB01099 n17:D00323 n18:3366 n19:46504735 n23:Flucytosine
n3:mechanismOfAction
Although the exact mode of action is unknown, it has been proposed that flucytosine acts directly on fungal organisms by competitive inhibition of purine and pyrimidine uptake and indirectly by intracellular metabolism to 5-fluorouracil. Flucytosine enters the fungal cell via cytosine permease; thus, flucytosine is metabolized to 5-fluorouracil within fungal organisms. The 5-fluorouracil is extensively incorporated into fungal RNA and inhibits synthesis of both DNA and RNA. The result is unbalanced growth and death of the fungal organism. It also appears to be an inhibitor of fungal thymidylate synthase.
n3:packager
n20:271B3EE2-363D-11E5-9242-09173F13E4C5 n20:271B3EE0-363D-11E5-9242-09173F13E4C5 n20:271B3EE1-363D-11E5-9242-09173F13E4C5 n20:271B3EDF-363D-11E5-9242-09173F13E4C5
n3:routeOfElimination
Flucytosine is excreted via the kidneys by means of glomerular filtration without significant tubular reabsorption. A small portion of the dose is excreted in the feces.
n3:synonym
5-Fluorocytosin Flucytosin Flucytosine Ancobon (tn) 5-FC 5-Flurocytosine Fluocytosine 5-Fluorocytosine 5-Fluorocystosine Fluorcytosine
n3:toxicity
Oral, rat: LD<sub>50</sub> = >15 gm/kg.
n3:proteinBinding
28-31%
n3:synthesisReference
Bernd Baasner, Erich Klauke, "Process for the preparation of 5-fluorocytosine." U.S. Patent US4703121, issued September, 1961.
n28:hasConcept
n29:M0008576
foaf:page
n22:flucytosine.htm n24:flucytosine.html
n3:IUPAC-Name
n4:271B3EEB-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B3EF1-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B3EF0-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B3EED-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B3EEE-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B3EEF-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B3F01-363D-11E5-9242-09173F13E4C5 n4:271B3EE9-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B3F03-363D-11E5-9242-09173F13E4C5 n4:271B3EE7-363D-11E5-9242-09173F13E4C5 n4:271B3EEA-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B3EE8-363D-11E5-9242-09173F13E4C5
n3:pKa
n4:271B3F04-363D-11E5-9242-09173F13E4C5
n8:hasATCCode
n9:J02AX01 n9:D01AE21
n3:H-Bond-Acceptor-Count
n4:271B3EF7-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B3EF8-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B3EF2-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B3EF3-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B3EF5-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B3EF4-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B3EF6-363D-11E5-9242-09173F13E4C5
n3:absorption
Rapidly and virtually completely absorbed following oral administration. Bioavailability 78% to 89%.
n3:affectedOrganism
Yeast and other fungi
n3:casRegistryNumber
2022-85-7
n3:category
n3:containedIn
n26:271B3EE4-363D-11E5-9242-09173F13E4C5 n26:271B3EE3-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n4:271B3EFD-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B3EFF-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B3F00-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B3F02-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B3EFC-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B3EFB-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B3EFE-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B3EEC-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B3EF9-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B3EFA-363D-11E5-9242-09173F13E4C5