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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n14http://linked.opendata.cz/resource/drugbank/drug/DB01096/identifier/kegg-compound/
n13http://linked.opendata.cz/resource/drugbank/drug/DB01096/identifier/pubchem-compound/
foafhttp://xmlns.com/foaf/0.1/
n20http://linked.opendata.cz/resource/drugbank/drug/DB01096/identifier/pubchem-substance/
n15http://linked.opendata.cz/resource/drugbank/drug/DB01096/identifier/kegg-drug/
n17http://linked.opendata.cz/resource/drugbank/drug/DB01096/identifier/drugbank/
n8http://bio2rdf.org/drugbank:
admshttp://www.w3.org/ns/adms#
n6http://www.drugs.com/mtm/
n21http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
owlhttp://www.w3.org/2002/07/owl#
n16http://linked.opendata.cz/resource/drugbank/drug/DB01096/identifier/chemspider/
n3http://linked.opendata.cz/ontology/drugbank/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n11http://linked.opendata.cz/resource/drugbank/drug/DB01096/identifier/pharmgkb/
n18http://linked.opendata.cz/ontology/sukl/drug/
n19http://linked.opendata.cz/resource/atc/
n10http://linked.opendata.cz/resource/drugbank/drug/DB01096/identifier/wikipedia/

Statements

Subject Item
n2:DB01096
rdf:type
n3:Drug
n3:description
An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martidale, The Extra Pharmacopoeia, 31st ed, p121)
n3:generalReferences
# Filho RP, de Souza Menezes CM, Pinto PL, Paula GA, Brandt CA, da Silveira MA: Design, synthesis, and in vivo evaluation of oxamniquine methacrylate and acrylamide prodrugs. Bioorg Med Chem. 2007 Feb 1;15(3):1229-36. Epub 2006 Nov 16. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17134907
n3:group
approved
n3:halfLife
1-2.5 hours
n3:indication
For treatment of Schistosomiasis caused by <i>Schistosoma mansoni</i>
owl:sameAs
n8:DB01096 n21:DB01096
dcterms:title
Oxamniquine
adms:identifier
n10:Oxamniquine n11:PA164748782 n13:4612 n14:C07341 n15:D00460 n16:4451 n17:DB01096 n20:46508789
n3:mechanismOfAction
Oxamniquine may associate with an irreversible inhibition of the nucleic acid metabolism of the parasites. A hypothesis has been put forth that the drug is activated by a single step, in which a schistosome sulfotransferase enzyme converts oxamniquine into an ester (probably acetate, phosphate, or sulfate). Subsequently, the ester spontaneously dissociates, the resulting electrophilic reactant is capable of alkylation of schistosome DNA.
n3:synonym
Vansil Mansil
n3:synthesisReference
"DrugSyn.org":http://www.drugsyn.org/Oxamniquine.htm
foaf:page
n6:oxamniquine.html
n3:IUPAC-Name
n4:271B6568-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B656E-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B656D-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B656A-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B656B-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B656C-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B6566-363D-11E5-9242-09173F13E4C5 n4:271B657E-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B3E70-363D-11E5-9242-09173F13E4C5 n4:271B6564-363D-11E5-9242-09173F13E4C5 n4:271B6567-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B6565-363D-11E5-9242-09173F13E4C5
n18:hasATCCode
n19:P02BA02
n3:H-Bond-Acceptor-Count
n4:271B6574-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B6575-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B656F-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B6570-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B6572-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B6571-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B6573-363D-11E5-9242-09173F13E4C5
n3:absorption
Well absorbed orally
n3:affectedOrganism
Schistosoma mansoni
n3:casRegistryNumber
21738-42-1
n3:Bioavailability
n4:271B657A-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B657C-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B657D-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B657F-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B6579-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B6578-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B657B-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B6569-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B6576-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B6577-363D-11E5-9242-09173F13E4C5