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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n10http://linked.opendata.cz/resource/drugbank/drug/DB01089/identifier/drugbank/
n5http://linked.opendata.cz/resource/mesh/concept/
n14http://linked.opendata.cz/resource/drugbank/drug/DB01089/identifier/chemspider/
n18http://bio2rdf.org/drugbank:
n13http://linked.opendata.cz/resource/drugbank/drug/DB01089/identifier/chebi/
admshttp://www.w3.org/ns/adms#
n17http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
n12http://linked.opendata.cz/resource/drugbank/drug/DB01089/identifier/pharmgkb/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n4http://linked.opendata.cz/ontology/mesh/
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n11http://linked.opendata.cz/resource/drugbank/drug/DB01089/identifier/kegg-compound/
n9http://linked.opendata.cz/resource/drugbank/drug/DB01089/identifier/pubchem-compound/
n6http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#
n8http://linked.opendata.cz/resource/drugbank/drug/DB01089/identifier/pubchem-substance/
n20http://linked.opendata.cz/resource/atc/
n19http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB01089
rdf:type
n3:Drug
n3:description
Deserpidine is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive properties that has been used for the control of high blood pressure and for the relief of psychotic behavior.
n3:group
approved
n3:indication
For the treatment of hypertension.
owl:sameAs
n17:DB01089 n18:DB01089
dcterms:title
Deserpidine
adms:identifier
n8:46505311 n9:8550 n10:DB01089 n11:C06541 n12:PA164742966 n13:27478 n14:8232
n3:mechanismOfAction
Deserpidine's mechanism of action is through inhibition of the ATP/Mg<sup>2+</sup> pump responsible for the sequestering of neurotransmitters into storage vesicles located in the presynaptic neuron. The neurotransmitters that are not sequestered in the storage vesicle are readily metabolized by monoamine oxidase (MAO) causing a reduction in catecholamines.
n3:synonym
Raunormine 11-desmethoxyreserpine Harmonyl Deserpidina (3beta,16beta,17alpha,18beta,20alpha)-17-Methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester Canescine Deserpidinum Recanescine 11-demethoxyreserpine Deserpidine
n3:toxicity
Symptoms of overdose include dizziness or drowsiness (severe), flushing of skin, pinpoint pupils of eyes and slowed pulse.
n3:synthesisReference
Gabriele Fontana, Ezio Bombardelli, Cristian Samori, Eleonora Baldelli, Andrea Guerrini, Arturo Battaglia, Bruno Danieli, "Process for the Semisynthesis of Deserpidine." U.S. Patent US20080242864, issued October 02, 2008.
n4:hasConcept
n5:M0262623
n3:IUPAC-Name
n6:271B647A-363D-11E5-9242-09173F13E4C5
n3:InChI
n6:271B6480-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n6:271B647F-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n6:271B647C-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n6:271B647D-363D-11E5-9242-09173F13E4C5
n3:SMILES
n6:271B647E-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n6:271B6478-363D-11E5-9242-09173F13E4C5
n3:logP
n6:271B6479-363D-11E5-9242-09173F13E4C5 n6:271B6476-363D-11E5-9242-09173F13E4C5 n6:271B6491-363D-11E5-9242-09173F13E4C5
n3:logS
n6:271B6477-363D-11E5-9242-09173F13E4C5
n19:hasATCCode
n20:C02AA05
n3:H-Bond-Acceptor-Count
n6:271B6486-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n6:271B6487-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n6:271B6481-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n6:271B6482-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n6:271B6484-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n6:271B6483-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n6:271B6485-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
131-01-1
n3:Bioavailability
n6:271B648C-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n6:271B648E-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n6:271B648F-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n6:271B6490-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n6:271B648B-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n6:271B648A-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n6:271B648D-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n6:271B647B-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n6:271B6488-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n6:271B6489-363D-11E5-9242-09173F13E4C5